2. MAPK/ERK Pathway
  3. JNK
  4. JNK3 inhibitor-3

JNK3 inhibitor-3 (compound 15g) is a selective, BBB permeable and orally active c-Jun N-terminal kinase 3 (JNK3) inhibitor. JNK3 inhibitor-3 has inhibitory activities to JNK1, JNK2 and JNK3 with IC50 values of 147.8, 44.0 and 4.1 nM, respectively. JNK3 inhibitor-3 significantly improves the memory in mouse dementia model. JNK3 inhibitor-3 can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

JNK3 inhibitor-3 Chemical Structure

JNK3 inhibitor-3 Chemical Structure

CAS No. : 2873465-25-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

JNK3 inhibitor-3 Related Antibodies

Top Publications Citing Use of Products

View All JNK Isoform Specific Products:

View All Isoforms
JNK1 JNK2 JNK3 JNK

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

JNK3 inhibitor-3 (compound 15g) is a selective, BBB permeable and orally active c-Jun N-terminal kinase 3 (JNK3) inhibitor. JNK3 inhibitor-3 has inhibitory activities to JNK1, JNK2 and JNK3 with IC50 values of 147.8, 44.0 and 4.1 nM, respectively. JNK3 inhibitor-3 significantly improves the memory in mouse dementia model. JNK3 inhibitor-3 can be used for the research of Alzheimer’s disease[1].

IC50 & Target

JNK3

4.1 nM (IC50)

JNK2

44 nM (IC50)

JNK1

147.8 nM (IC50)

In Vitro

JNK3 inhibitor-3 (0-10 μM) shows inhibitory activities to JNK1, JNK2 and JNK3 with IC50 values of 147.8, 44.0 and 4.1 nM, respectively[1]. JNK3 inhibitor-3 (20 μM; 24 and 48 h) demonstrates neuroprotective effects in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNK3 inhibitor-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: Rat cortical neurons
Concentration: 20 μM
Incubation Time: 24 and 48 hours
Result: Protected rat cortical neurons against 10 μM Aβ1-42 induced neurotoxicity.
In Vivo

JNK3 inhibitor-3 (30 and 60 mg/kg; oral administration, once daily for 2 or 2.2 month) improves the memory of 3xTg mouse dementia model[1].
1.19 Pharmacokinetic Properties of JNK3 inhibitor-3 in Rats[1].

Rats
IV 1 mg/kg		 Rats
PO 3 mg/kg
AUC (hr•ng/mL) 1085.24 2806.77
Cmax (ng/mL) 1238.85
Tmax (hr) 0.67
T1/2 (hr) 0.36 1.14
BA (%) 86.21

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Homozygous 3xTg and APPswe/PS1dE9 double-transgenic mice model of Alzheimer’s disease[1]
Dosage: 30 and 60 mg/kg
Administration: Oral administration; once daily for 2 or 2.2 month
Result: Induced no abnormal symptoms or weight changes, significantly enhanced the spontaneous alteration in APP/PS1 and doses of 30 and 60 mg/kg than that of vehicle group in Y-maze test and showed a significant difference compared to the 3xTg vehicle control in the passive avoidance test.
Molecular Weight

467.52

Formula

C26H25N7O2
CAS No.
SMILES

N#CCC1=CN=C(N1C2=NC(N[C@H]3CCCN(C3)C(C4CC4)=O)=NC=C2)C5=CC6=C(OC=C6)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

JNK3 inhibitor-3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK3 inhibitor-32873465-25-7JNKc-Jun N-terminal kinaseselectiveBBB permeablemouse dementia modelAlzheimer’s diseaseneuroprotectiveneuronsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
JNK3 inhibitor-3
Cat. No.:
HY-151928
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.