2873465-25-7
Chemical Structure
JNK3 inhibitor-3
- CAS No.: 2873465-25-7
- Formula:C26H25N7O2
- Molecular Weight:467.52
IUPAC Name: (S)-2-(2-(benzofuran-5-yl)-1-(2-((1-(cyclopropanecarbonyl)piperidin-3-yl)amino)pyrimidin-4-yl)-1H-imidazol-5-yl)acetonitrile
InChIKey: ZBEPMOZEXLGCTF-FQEVSTJZSA-N
SMILES: N#CCC1=CN=C(N1C2=NC(N[C@H]3CCCN(C3)C(C4CC4)=O)=NC=C2)C5=CC6=C(OC=C6)C=C5
Biological Activity: JNK3 inhibitor-3 (compound 15g) is a selective, BBB permeable and orally active c-Jun N-terminal kinase 3 (JNK3) inhibitor. JNK3 inhibitor-3 has inhibitory activities to JNK1, JNK2 and JNK3 with IC50 values of 147.8, 44.0 and 4.1 nM, respectively. JNK3 inhibitor-3 significantly improves the memory in mouse dementia model. JNK3 inhibitor-3 can be used for the research of Alzheimer’s disease[1].
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JNK3 inhibitor-3 | JNK3 inhibitor-3 (compound 15g) is a selective, BBB permeable and orally active c-Jun N-terminal kinase 3 (JNK3) inhibitor. JNK3 inhibitor-3 has inhibitory activities to JNK1, JNK2 and JNK3 with IC50 values of 147.8, 44.0 and 4.1 nM, respectively. JNK3 inhibitor-3 significantly improves the memory in mouse dementia model. JNK3 inhibitor-3 can be used for the research of Alzheimer’s disease. | |||||||||||||||||||||
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Keywords
