1. MAPK/ERK Pathway
  2. JNK
  3. IQ-3

IQ-3 

Cat. No.: HY-107600
Handling Instructions

IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively.

For research use only. We do not sell to patients.

IQ-3 Chemical Structure

IQ-3 Chemical Structure

CAS No. : 312538-03-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
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25 mg USD 280 In-stock
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50 mg USD 450 In-stock
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100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively[1].

IC50 & Target[1]

JNK3

0.066 μM (Kd)

JNK1

0.24 μM (Kd)

JNK2

0.29 μM (Kd)

CK1δ

0.56 μM (Kd)

PI3Kγ

0.43 μM (Kd)

MKNK2

1.2 μM (Kd)

In Vitro

IQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively[1].
IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells[1].
IQ-3 is indeed a competitive inhibitor for the ATP binding site of JNK3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PBMCs.
Concentration: 0-80 μM (200 ng/mL LPS).
Incubation Time: 30 min.
Result: Downregulated TNF-α concentration (IC50 = 4.7 μM).
Molecular Weight

341.32

Formula

C₂₀H₁₁N₃O₃

CAS No.

312538-03-7

SMILES

O=C(O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2)C5=CC=CO5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (73.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9298 mL 14.6490 mL 29.2980 mL
5 mM 0.5860 mL 2.9298 mL 5.8596 mL
10 mM 0.2930 mL 1.4649 mL 2.9298 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

IQ-3IQ3IQ 3JNKc-Jun N-terminal kinaseTNF-αIL-6IL-1αIL-1βInhibitorinhibitorinhibit

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IQ-3
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HY-107600
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