2. Gene
  3. FIGNL1 - fidgetin like 1 Gene

FIGNL1 - fidgetin like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 63979 | Gene type: protein coding

About FIGNL1

Cytogenetic location: 7p12.2 Genomic coordinates (GRCh38): 7:50,444,133-50,450,350 (from NCBI)

This gene has 14 transcripts (splice variants), 182 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 1.9), appendix (RPKM 1.8) and 24 other tissues.

Summary

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016]

FIGNL1 Products(15)

mRNA Protein Name
NM_001042762.5 NP_001036227.1 fidgetin-like protein 1 isoform 1
NM_001287492.4 NP_001274421.1 fidgetin-like protein 1 isoform 1
NM_001287493.3 NP_001274422.1 fidgetin-like protein 1 isoform 1
NM_001287494.4 NP_001274423.1 fidgetin-like protein 1 isoform 1
NM_001287495.3 NP_001274424.1 fidgetin-like protein 1 isoform 1
NM_001287496.4 NP_001274425.1 fidgetin-like protein 1 isoform 2
NM_001346558.3 NP_001333487.1 fidgetin-like protein 1 isoform 2
NM_001346559.3 NP_001333488.1 fidgetin-like protein 1 isoform 2
NM_001346560.3 NP_001333489.1 fidgetin-like protein 1 isoform 1
NM_001346561.3 NP_001333490.1 fidgetin-like protein 1 isoform 1
NM_001346562.3 NP_001333491.1 fidgetin-like protein 1 isoform 1
NM_001346563.3 NP_001333492.1 fidgetin-like protein 1 isoform 1
NM_001346564.3 NP_001333493.1 fidgetin-like protein 1 isoform 1
NM_001346565.3 NP_001333494.1 fidgetin-like protein 1 isoform 1
NM_022116.7 NP_071399.2 fidgetin-like protein 1 isoform 1

FIGNL1 Protein Structure

AAA

AAA: ATPase family associated with various cellular activities (AAA) (437 - 566)

Vps4_C

Vps4_C: Vps4 C terminal oligomerisation domain (638 - 671)

  • 0
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  • 674 a.a.
Protein Preferred Names Protein Names

fidgetin-like protein 1

Related Diseases

Diseases Alias
Hermansky-Pudlak Syndrome 3

HPS3

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Delta Storage Pool Disease

Hermansky-Pudlak Syndrome, Type 3

Platelet Storage Pool Deficiency

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Third Cranial Nerve Disease

Disorder Of Oculomotor Nerve

Oculomotor Nerve Disorder

Oculomotor Nerve Paralysis

Third Cranial Nerve Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04947 FIGNL1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FIGNL1 MGD MGI:1890648
Canis familiaris FIGNL1 VGNC VGNC:40880
Bos taurus FIGNL1 VGNC VGNC:29011
Rattus norvegicus FIGNL1 RGD RGD:1307112
Macaca mulatta FIGNL1 VGNC VGNC:72483