FIGNL1 - fidgetin like 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 63979

About FIGNL1

Cytogenetic location: 7p12.2 Genomic coordinates (GRCh38): 7:50,444,133-50,450,350 (from NCBI)

This gene has 14 transcripts (splice variants), 182 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 1.9), appendix (RPKM 1.8) and 24 other tissues.

Summary

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016]

FIGNL1 Products (15)

mRNA	Protein	Name
NM_001042762.5	NP_001036227.1	fidgetin-like protein 1 isoform 1
NM_001287492.4	NP_001274421.1	fidgetin-like protein 1 isoform 1
NM_001287493.3	NP_001274422.1	fidgetin-like protein 1 isoform 1
NM_001287494.4	NP_001274423.1	fidgetin-like protein 1 isoform 1
NM_001287495.3	NP_001274424.1	fidgetin-like protein 1 isoform 1
NM_001287496.4	NP_001274425.1	fidgetin-like protein 1 isoform 2
NM_001346558.3	NP_001333487.1	fidgetin-like protein 1 isoform 2
NM_001346559.3	NP_001333488.1	fidgetin-like protein 1 isoform 2
NM_001346560.3	NP_001333489.1	fidgetin-like protein 1 isoform 1
NM_001346561.3	NP_001333490.1	fidgetin-like protein 1 isoform 1
NM_001346562.3	NP_001333491.1	fidgetin-like protein 1 isoform 1
NM_001346563.3	NP_001333492.1	fidgetin-like protein 1 isoform 1
NM_001346564.3	NP_001333493.1	fidgetin-like protein 1 isoform 1
NM_001346565.3	NP_001333494.1	fidgetin-like protein 1 isoform 1
NM_022116.7	NP_071399.2	fidgetin-like protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23754376	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	23754376	GOA
involved in regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	23754376	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nuclear chromosome	IDA IDA: Inferred from direct assay	23754376	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FIGNL1 Protein Structure

AAA

Vps4_C

0
200
400
600
674 a.a.

Protein Preferred Names	Protein Names
fidgetin-like protein 1

FIGNL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FIGNL1	Q6PIW4	ITGB1BP1	Homo sapiens	O14713	Y2H Array	25416956
Intra	FIGNL1	Q6PIW4	GCC1	Homo sapiens	Q96CN9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hermansky-Pudlak Syndrome 3	HPS3 Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Delta Storage Pool Disease Hermansky-Pudlak Syndrome, Type 3 Platelet Storage Pool Deficiency Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Third Cranial Nerve Disease	Disorder Of Oculomotor Nerve Oculomotor Nerve Disorder Oculomotor Nerve Paralysis Third Cranial Nerve Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04947	FIGNL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FIGNL1	MGD	MGI:1890648
Canis familiaris	FIGNL1	VGNC	VGNC:40880
Bos taurus	FIGNL1	VGNC	VGNC:29011
Rattus norvegicus	FIGNL1	RGD	RGD:1307112
Macaca mulatta	FIGNL1	VGNC	VGNC:72483
Others	FIGNL1	NCBI