ITGB1BP1 - integrin subunit beta 1 binding protein 1 Gene

Homo sapiens

Also known as ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha

Gene ID: 9270 | Gene type: protein coding

About ITGB1BP1

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:9,403,475-9,423,569 (from NCBI)

This gene has 21 transcripts (splice variants) and 217 orthologues. Broad expression in fat (RPKM 65.6), brain (RPKM 11.2) and 22 other tissues.

Summary

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 Integrin cytoplasmic domain. The interaction between this protein and beta1 Integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 Integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

ITGB1BP1 Products(14)

mRNA	Protein	Name
NM_001319066.2	NP_001305995.1	integrin beta-1-binding protein 1 isoform 1
NM_001319067.2	NP_001305996.1	integrin beta-1-binding protein 1 isoform 1
NM_001319068.2	NP_001305997.1	integrin beta-1-binding protein 1 isoform 1
NM_001319069.2	NP_001305998.1	integrin beta-1-binding protein 1 isoform 3
NM_001319070.2	NP_001305999.1	integrin beta-1-binding protein 1 isoform 4
NM_001369744.1	NP_001356673.1	integrin beta-1-binding protein 1 isoform 1
NM_001369745.1	NP_001356674.1	integrin beta-1-binding protein 1 isoform 1
NM_001369746.1	NP_001356675.1	integrin beta-1-binding protein 1 isoform 1
NM_001369747.1	NP_001356676.1	integrin beta-1-binding protein 1 isoform 2
NM_001369748.1	NP_001356677.1	integrin beta-1-binding protein 1 isoform 1
NM_001369749.2	NP_001356678.1	integrin beta-1-binding protein 1 isoform 1
NM_001369750.1	NP_001356679.1	integrin beta-1-binding protein 1 isoform 2
NM_004763.5	NP_004754.1	integrin beta-1-binding protein 1 isoform 1
NM_022334.5	NP_071729.1	integrin beta-1-binding protein 1 isoform 2

ITGB1BP1 Protein Structure

ICAP-1_inte_bdg

0
100
200 a.a.

Protein Preferred Names

Protein Names

integrin beta-1-binding protein 1

bodenin

Related Diseases

Diseases

Alias

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Angioma Serpiginosum

Angioma Serpiginosum Of Skin

Angioma Serpiginosum, X-Linked

Cavernous Hemangioma

Hemangioma, Cavernous	Cavernoma
Cavernous Haemangioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06964	ITGB1BP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ITGB1BP1	VGNC	VGNC:42137
Rattus norvegicus	ITGB1BP1	RGD	RGD:1307810
Macaca mulatta	ITGB1BP1	VGNC	VGNC:73643
Felis catus	ITGB1BP1	VGNC	VGNC:80123
Bos taurus	ITGB1BP1	VGNC	VGNC:30325
Mus musculus	ITGB1BP1	MGD	MGI:1306802

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