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ITGB1BP1 - integrin subunit beta 1 binding protein 1 Gene

Also Known as ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9270

About ITGB1BP1

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:9,403,475-9,423,569 (from NCBI)

This gene has 21 transcripts (splice variants) and 217 orthologues. Broad expression in fat (RPKM 65.6), brain (RPKM 11.2) and 22 other tissues.

Summary

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 Integrin cytoplasmic domain. The interaction between this protein and beta1 Integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 Integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

ITGB1BP1 Products (14)

mRNA	Protein	Name
NM_001319066.2	NP_001305995.1	integrin beta-1-binding protein 1 isoform 1
NM_001319067.2	NP_001305996.1	integrin beta-1-binding protein 1 isoform 1
NM_001319068.2	NP_001305997.1	integrin beta-1-binding protein 1 isoform 1
NM_001319069.2	NP_001305998.1	integrin beta-1-binding protein 1 isoform 3
NM_001319070.2	NP_001305999.1	integrin beta-1-binding protein 1 isoform 4
NM_001369744.1	NP_001356673.1	integrin beta-1-binding protein 1 isoform 1
NM_001369745.1	NP_001356674.1	integrin beta-1-binding protein 1 isoform 1
NM_001369746.1	NP_001356675.1	integrin beta-1-binding protein 1 isoform 1
NM_001369747.1	NP_001356676.1	integrin beta-1-binding protein 1 isoform 2
NM_001369748.1	NP_001356677.1	integrin beta-1-binding protein 1 isoform 1
NM_001369749.2	NP_001356678.1	integrin beta-1-binding protein 1 isoform 1
NM_001369750.1	NP_001356679.1	integrin beta-1-binding protein 1 isoform 2
NM_004763.5	NP_004754.1	integrin beta-1-binding protein 1 isoform 1
NM_022334.5	NP_071729.1	integrin beta-1-binding protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GDP-dissociation inhibitor activity	IDA IDA: Inferred from direct assay	11807099	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	15703214	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	12473654	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9281591	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of protein kinase B activity	IDA IDA: Inferred from direct assay	20616313	GOA
involved in blood vessel diameter maintenance	IDA IDA: Inferred from direct assay	20616313	GOA
involved in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	20616313	GOA
involved in cell-matrix adhesion	IDA IDA: Inferred from direct assay	9281591	GOA
involved in cellular response to fibroblast growth factor stimulus	IDA IDA: Inferred from direct assay	20616313	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	20616313	GOA
involved in integrin activation	IDA IDA: Inferred from direct assay	23317506	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	11919189	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20616313	GOA
involved in negative regulation of cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	20616313	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	20616313	GOA
involved in negative regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	12473654	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	12473654	GOA
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	20616313	GOA
involved in negative regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	11807099	GOA
involved in negative regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	11807099	GOA
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	20616313	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15703214	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	20616313	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	20616313	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15703214	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	17916086	GOA
involved in regulation of GTPase activity	IDA IDA: Inferred from direct assay	11807099	GOA
involved in tube formation	IDA IDA: Inferred from direct assay	20616313	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell periphery	IDA IDA: Inferred from direct assay	11919189	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11919189	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11919189	GOA
NOT located in focal adhesion	IDA IDA: Inferred from direct assay	11919189	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	11919189	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12473654	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11919189	GOA
located in ruffle	IDA IDA: Inferred from direct assay	11919189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB1BP1 Protein Structure

ICAP-1_inte_bdg

0
100
200 a.a.

Protein Preferred Names	Protein Names
integrin beta-1-binding protein 1	bodenin

ITGB1BP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ITGB1BP1	O14713	RHOH	Homo sapiens	Q15669	Y2H Prey Pooling	32296183
Intra	ITGB1BP1	O14713	RHOH	Homo sapiens	Q15669	Validated Y2H	32296183
Intra	ITGB1BP1	O14713	RHOH	Homo sapiens	Q15669	Y2H Array	32296183
Intra	ITGB1BP1	O14713	KRIT1	Homo sapiens	O00522	Y2H Array	25814554
Intra	ITGB1BP1	O14713	DLD	Homo sapiens	P09622	Validated Y2H	32296183
Intra	ITGB1BP1	O14713	DLD	Homo sapiens	P09622	Y2H Array	32296183
Intra	ITGB1BP1	O14713	DLD	Homo sapiens	P09622	Y2H Prey Pooling	32296183
Intra	ITGB1BP1	O14713	FIGNL1	Homo sapiens	Q6PIW4	Y2H Prey Pooling	25416956
Intra	ITGB1BP1	O14713	FIGNL1	Homo sapiens	Q6PIW4	Validated Y2H	25416956
Intra	ITGB1BP1	O14713	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	ITGB1BP1	O14713	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	ITGB1BP1	O14713	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	ITGB1BP1	O14713	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	ITGB1BP1	O14713	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	ITGB1BP1	O14713	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	ITGB1BP1	O14713	SOD1	Homo sapiens	P00441	Validated Y2H	32814053
Intra	ITGB1BP1	O14713	SOD1	Homo sapiens	P00441	Y2H Array	32814053
Intra	ITGB1BP1	O14713	SOD1	Homo sapiens	P00441	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Cerebrocostomandibular Syndrome	Cerebro-Costo-Mandibular Syndrome CCMS Rib Gap Defects With Micrognathia Ccm Syndrome
Angioma Serpiginosum	Angioma Serpiginosum Of Skin Angioma Serpiginosum, X-Linked
Cavernous Hemangioma	Hemangioma, Cavernous Cavernoma Cavernous Haemangioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06964	ITGB1BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ITGB1BP1	VGNC	VGNC:42137
Rattus norvegicus	ITGB1BP1	RGD	RGD:1307810
Macaca mulatta	ITGB1BP1	VGNC	VGNC:73643
Felis catus	ITGB1BP1	VGNC	VGNC:80123
Bos taurus	ITGB1BP1	VGNC	VGNC:30325
Mus musculus	ITGB1BP1	MGD	MGI:1306802
Others	ITGB1BP1	NCBI