RHOH - ras homolog family member H Gene

Homo sapiens

Also known as TTF; ARHH

Gene ID: 399 | Gene type: protein coding

About RHOH

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:40,191,080-40,246,967 (from NCBI)

This gene has 17 transcripts (splice variants), 184 orthologues, 22 paralogues and is associated with 53 phenotypes. Biased expression in lymph node (RPKM 20.2), bone marrow (RPKM 10.8) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

RHOH Products(12)

mRNA	Protein	Name
NM_001278359.2	NP_001265288.1	rho-related GTP-binding protein RhoH precursor
NM_001278360.2	NP_001265289.1	rho-related GTP-binding protein RhoH precursor
NM_001278361.2	NP_001265290.1	rho-related GTP-binding protein RhoH precursor
NM_001278362.2	NP_001265291.1	rho-related GTP-binding protein RhoH precursor
NM_001278363.2	NP_001265292.1	rho-related GTP-binding protein RhoH precursor
NM_001278364.2	NP_001265293.1	rho-related GTP-binding protein RhoH precursor
NM_001278365.2	NP_001265294.1	rho-related GTP-binding protein RhoH precursor
NM_001278366.2	NP_001265295.1	rho-related GTP-binding protein RhoH precursor
NM_001278367.2	NP_001265296.1	rho-related GTP-binding protein RhoH precursor
NM_001278368.2	NP_001265297.1	rho-related GTP-binding protein RhoH precursor
NM_001278369.2	NP_001265298.1	rho-related GTP-binding protein RhoH precursor
NM_004310.5	NP_004301.1	rho-related GTP-binding protein RhoH precursor

RHOH Protein Structure

Ras

0
100
191 a.a.

Protein Preferred Names

Protein Names

rho-related GTP-binding protein RhoH

GTP-binding protein TTF

Related Diseases

Diseases

Alias

Epidermodysplasia Verruciformis 4

Epidermodysplasia Verruciformis, Susceptibility To, 4	EV4
T-Cell Immunodeficiency With Epidermodysplasia Verruciformis	T-Cell Immunodeficiency Due To Rhoh Deficiency
{Epidermodysplasia Verruciformis, Susceptibility To, 4}

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Pityriasis Versicolor

Tinea Versicolor

Infection By Pityrosporum Furfur

Skin Carcinoma

Skin Cancer	Carcinoma Of Skin
Ca - Skin Cancer	Cancer Of Skin
Malignant Neoplasm Of Skin	Melanoma And Non-Melanoma Skin Cancer
Skin Cancers	Cancer, Skin

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11954	RHOH Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RHOH	VGNC	VGNC:68162
Canis familiaris	RHOH	VGNC	VGNC:45561
Macaca mulatta	RHOH	VGNC	VGNC:76884
Mus musculus	RHOH	MGD	MGI:1921984
Bos taurus	RHOH	VGNC	VGNC:33950
Rattus norvegicus	RHOH	RGD	RGD:1307623