KRT6B - keratin 6B Gene

Also Known as K6B; PC2; PC4; CK6B; CK-6B; KRTL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3854

About KRT6B

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,446,651-52,452,146 (from NCBI)

This gene has 1 transcript (splice variant), 143 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward esophagus (RPKM 785.7).

Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

KRT6B Products (1)

mRNA	Protein	Name
NM_005555.4	NP_005546.2	keratin, type II cytoskeletal 6B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT6B Protein Structure

Filament

0
100
200
300
400
500
564 a.a.

Protein Preferred Names	Protein Names
keratin, type II cytoskeletal 6B	cytokeratin 6B

KRT6B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT6B	P04259	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	KRT6B	P04259	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	KRT6B	P04259	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT38	Homo sapiens	O76015	Validated Y2H	25416956
Intra	KRT6B	P04259	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	KRT6B	P04259	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
Intra	KRT6B	P04259	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT38	Homo sapiens	O76015	MAPPIT	32296183
Intra	KRT6B	P04259	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KRT6B	P04259	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT6B	P04259	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT6B	P04259	TUBGCP4	Homo sapiens	Q9UGJ1-2	Y2H Array	32296183
Intra	KRT6B	P04259	TUBGCP4	Homo sapiens	Q9UGJ1-2	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	TUBGCP4	Homo sapiens	Q9UGJ1-2	Validated Y2H	32296183
Intra	KRT6B	P04259	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	25416956
Intra	KRT6B	P04259	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	KRT6B	P04259	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	KRT6B	P04259	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	KRT6B	P04259	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	KRT6B	P04259	TEX11	Homo sapiens	Q8IYF3-3	Y2H Array	32296183
Intra	KRT6B	P04259	TEX11	Homo sapiens	Q8IYF3-3	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	TEX11	Homo sapiens	Q8IYF3-3	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT39	Homo sapiens	Q6A163	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	KRT6B	P04259	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT6B	P04259	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT28	Homo sapiens	Q7Z3Y7	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT28	Homo sapiens	Q7Z3Y7	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT28	Homo sapiens	Q7Z3Y7	Y2H Array	32296183
Intra	KRT6B	P04259	KRT13	Homo sapiens	P13646	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT13	Homo sapiens	P13646	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT13	Homo sapiens	P13646	Y2H Array	32296183
Intra	KRT6B	P04259	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	KRT6B	P04259	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	KRT6B	P04259	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	KRT6B	P04259	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	KRT6B	P04259	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	KRT6B	P04259	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	KRT6B	P04259	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	KRT6B	P04259	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT6B	P04259	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	NUP62	Homo sapiens	P37198	Validated Y2H	32296183
Intra	KRT6B	P04259	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	KRT6B	P04259	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	KRT6B	P04259	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	KRT6B	P04259	NDC80	Homo sapiens	O14777	Y2H Prey Pooling	25416956
Intra	KRT6B	P04259	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT6B	P04259	KRT15	Homo sapiens	P19012	Y2H Pooling	16189514
Intra	KRT6B	P04259	KRT15	Homo sapiens	P19012	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	KRT6B	P04259	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT19	Homo sapiens	P08727	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT6B	P04259	KRT19	Homo sapiens	P08727	Y2H Pooling	16189514
Intra	KRT6B	P04259	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KRT6B	P04259	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	KRT6B	P04259	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	KRT6B	P04259	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

KRT6B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85990	Cytokeratin 6 Antibody (YA5682)	IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Pachyonychia Congenita 4	PC4 Pachyonychia Congenita, Type 4
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2
Pachyonychia Congenita 2	Pachyonychia Congenita, Type 2 PC2 Pachyonychia Congenita, Jackson-Lawler Type, Formerly Pachyonychia Congenita Jackson-Lawler Type
Median Rhomboid Glossitis	Persistent Tuberculum Impar Glossitis Rhomboidea Mediana Superficial Midline Glossitis
Glossitis	Inflammation Of Tongue Tongue Inflammation Glazed Tongue
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse	PPKNEFD Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse
Cataract 38	CTRCT38 Catc5 Autosomal Recessive Congenital Cataract 5 Cataract, Autosomal Recessive Congenital 5 Cataract 38, Autosomal Recessive Cataract, Type 38
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1	Focal Nonepidermolytic Palmoplantar Keratoderma Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma FNEPPK1 Ppkfne Keratoderma, Focal Nonepidermolytic Palmoplantar Palmoplantar Keratoderma, Nonepidermolytic, Focal Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Fneppk Focal Nonepidermolytic Palmoplantar Keratoderma 1 Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1 Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Steatocystoma Multiplex	Sebocystomatosis Multiple Sebaceous Cysts Multiplex Steatocystoma Sebaceous Cysts, Multiple SM
Focal Palmoplantar Keratoderma	Focal Ppk Focal Keratosis Palmoplantaris Focal Palmoplantar Hyperkeratosis
Occupational Dermatitis	Dermatitis, Occupational Occupational Allergic Contact Dermatitis Occupational Eczema
Palmoplantar Keratoderma, Epidermolytic	Epidermolytic Palmoplantar Keratoderma EPPK Keratosis Palmaris Et Plantaris Familiaris Tylosis Keratosis Of Greither Diffuse Nonepidermolytic Palmoplantar Keratoderma Keratoderma, Palmoplantar, Epidermolytic Unna-Thost Palmoplantar Keratoderma Epidermolytic Palmoplantar Keratoderma Of Voerner Ppke Keratoderma, Epidermolytic Palmoplantar Palmoplantar Keratoderma, Vorner Type Hyperkeratosis, Localized Epidermolytic Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type Epidermolytic Palmoplantar Keratoderma Of Vörner Hyperkeratosis Palmoplantar Localized Epidermolytic Diffuse Neppk Ppk Diffusa Circumscripta Thost-Unna Disease Thost-Unna Palmoplantar Keratoderma Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type Epidermolytic Palmoplantar Keratoderma Of Vorner Ehppk Epidermolytic Unna-Thost Disease Localized Epidermolytic Hyperkeratosis Palmoplantar Keratoderma Vorner Type Unilateral Palmoplantar Verrucous Nevus UPVN Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Palmoplantar Keratoderma, Nonepidermolytic Epidermolytic Palmoplantar Keratoderma Vorner Type Type B Tylosis Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Type A Tylosis
Naegeli-Franceschetti-Jadassohn Syndrome	Naegeli Syndrome Nfj Syndrome NFJS Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis Dpr Franceschetti-Jadassohn Syndrome Nfjs/Dpr
White Sponge Nevus 1	White Sponge Nevus Of Cannon Leukokeratosis, Hereditary Mucosal Hereditary Mucosal Leukokeratosis White Sponge Nevus WSN1 Wsn Cannon'S Disease Familial White Folded Mucosal Dysplasia Hereditary Leukokeratosis Hereditary Oral Keratosis Leukokeratosis Of Oral Mucosa Nevus Of Cannon White Folded Gingivostomatosis White Gingivostomatitis White Sponge Naevus White Sponge Nevus Of Mucosa
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Palmoplantar Keratosis	Palmoplantar Keratoderma Keratosis Palmaris Et Plantaris Palmo-Plantar Keratodermas Keratoderma, Palmoplantar Keratoderma Palmoplantar Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Of Palms And Soles Palmoplantar Hyperkeratosis
Angular Cheilitis	Cheilosis Angular Cheilosis Angular Stomatitis Commissural Cheilitis
Epidermolysis Bullosa Simplex 1a, Generalized Severe	Epidermolysis Bullosa Simplex, Dowling-Meara Type Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type EBS1A Ebsdm Epidermolysis Bullosa Simplex Dowling-Meara Type Epidermolysis Bullosa Simplex, Herpetiformis Ebs-Dm Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type Ebs-Gen Sev Epidermolysis Bullosa Herpetiformis Dowling-Meara Type Generalized Severe Epidermolysis Bullosa Simplex Dowling-Meara Type Epidermolysis Bullosa Simplex Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form Autosomal Dominant Generalized Ebs, Severe Form Epidermolysis Bullosa Simplex Herpetiformis Dm-Ebs Epidermolysis Bullosa Simplex, Generalized Severe Epidermolysis Bullosa Herpetiformis, Dowling-Meara Epidermolysis Bullosa Herpetiformis Dowling-Meara
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07459	KRT6B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22603	Krt6b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown