SPC25 - SPC25 component of NDC80 kinetochore complex Gene

Also Known as AD024; SPBC25; hSpc25

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57405

About SPC25

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:168,861,521-168,890,430 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele and 199 orthologues. Broad expression in lymph node (RPKM 4.1), bone marrow (RPKM 2.8) and 19 other tissues.

Summary

This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]

SPC25 Products (1)

mRNA	Protein	Name
NM_020675.4	NP_065726.1	kinetochore protein Spc25

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14699129	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in attachment of spindle microtubules to kinetochore	IDA IDA: Inferred from direct assay	18455984	GOA
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	14699129	GOA
involved in mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	14699129	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Ndc80 complex	IDA IDA: Inferred from direct assay	14699129	GOA
part of Ndc80 complex	IPI IPI: Inferred from physical interaction	18455984	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	14699129	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	24530301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPC25 Protein Structure

Spindle_Spc25

0
100
200
224 a.a.

Protein Preferred Names	Protein Names
kinetochore protein Spc25	2600017H08Rik

SPC25 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SPC25	Q9HBM1	NDC80	Homo sapiens	O14777	Anti Tag CoIP	33961781
Intra	SPC25	Q9HBM1	NDC80	Homo sapiens	O14777	Anti Tag CoIP	28514442
Intra	SPC25	Q9HBM1	NDC80	Homo sapiens	O14777	Anti Tag CoIP	14699129
Intra	SPC25	Q9HBM1	SPC24	Homo sapiens	Q8NBT2	Y2H Array	32296183
Intra	SPC25	Q9HBM1	SPC24	Homo sapiens	Q8NBT2	Anti Tag CoIP	33961781
Intra	SPC25	Q9HBM1	SPC24	Homo sapiens	Q8NBT2	Affinity Chrom	15961401
Intra	SPC25	Q9HBM1	SPC24	Homo sapiens	Q8NBT2	Y2H Prey Pooling	32296183
Intra	SPC25	Q9HBM1	SPC24	Homo sapiens	Q8NBT2	IF	14738735

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Diffuse Idiopathic Skeletal Hyperostosis	Hyperostosis, Diffuse Idiopathic Skeletal Ankylosing Vertebral Hyperostosis Dish Disseminated Idiopathic Skeletal Hyperostosis Forestier Disease Forestier'S Disease Hyperostosis Diffuse Idiopathic Skeletal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13648	SPC25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21766	Spc25 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SPC25	RGD	RGD:1307811
Felis catus	SPC25	VGNC	VGNC:65625
Bos taurus	SPC25	VGNC	VGNC:35196
Mus musculus	SPC25	MGD	MGI:1913692
Canis familiaris	SPC25	VGNC	VGNC:46724
Macaca mulatta	SPC25	VGNC	VGNC:104556
Others	SPC25	NCBI