SPC24 - SPC24 component of NDC80 kinetochore complex Gene

Also Known as SPBC24

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 147841

About SPC24

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,145,493-11,155,782 (from NCBI)

This gene has 7 transcripts (splice variants) and 170 orthologues. Broad expression in bone marrow (RPKM 2.7), lymph node (RPKM 1.3) and 16 other tissues.

Summary

Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Apr 2022]

SPC24 Products (8)

mRNA Protein Name
NM_001317031.2 NP_001303960.1 kinetochore protein Spc24 isoform 2
NM_001317032.2 NP_001303961.1 kinetochore protein Spc24 isoform 3
NM_001394314.1 NP_001381243.1 kinetochore protein Spc24 isoform 5
NM_001394315.1 NP_001381244.1 kinetochore protein Spc24 isoform 6
NM_001394316.1 NP_001381245.1 kinetochore protein Spc24 isoform 7
NM_001394317.1 NP_001381246.1 kinetochore protein Spc24 isoform 8
NM_001394318.1 NP_001381247.1 kinetochore protein Spc24 isoform 9
NM_182513.4 NP_872319.1 kinetochore protein Spc24 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14738735 GOA
Biological Process GO Annotation Evidence References Source
involved in attachment of spindle microtubules to kinetochore IDA
IDA: Inferred from direct assay
18455984 GOA
Cellular Component GO Annotation Evidence References Source
part of Ndc80 complex IDA
IDA: Inferred from direct assay
14699129 GOA
part of Ndc80 complex IPI
IPI: Inferred from physical interaction
18455984 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
15961401 GOA
part of outer kinetochore IDA
IDA: Inferred from direct assay
24530301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPC24 Protein Structure

Spc24

Spc24: Spc24 subunit of Ndc80 (81 - 192)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

kinetochore protein Spc24

  • SPC24, NDC80 kinetochore complex component, homolog

SPC24 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPC24 Q8NBT2 WHRN Homo sapiens Q9P202
Validated Y2H
32296183
Intra
SPC24 Q8NBT2 SPC25 Homo sapiens Q9HBM1
Pull Down
15961401
Intra
SPC24 Q8NBT2 SPC25 Homo sapiens Q9HBM1
Anti Tag CoIP
28514442
Intra
SPC24 Q8NBT2 SPC25 Homo sapiens Q9HBM1
Y2H Array
32296183
Intra
SPC24 Q8NBT2 SPC25 Homo sapiens Q9HBM1
Anti Tag CoIP
33961781
Intra
SPC24 Q8NBT2 SPC25 Homo sapiens Q9HBM1
Y2H Prey Pooling
32296183
Intra
SPC24 Q8NBT2 SPC25 Homo sapiens Q9HBM1
Anti Tag CoIP
26496610
Intra
SPC24 Q8NBT2 SPC25 Homo sapiens Q9HBM1
GMS
15961401
Intra
SPC24 Q8NBT2 SPC25 Homo sapiens Q9HBM1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13647 SPC24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SPC24 VGNC VGNC:46723
Rattus norvegicus SPC24 RGD RGD:1307631
Felis catus SPC24 VGNC VGNC:80725
Macaca mulatta SPC24 VGNC VGNC:78002
Bos taurus SPC24 VGNC VGNC:35195
Mus musculus SPC24 MGD MGI:1914879
Others SPC24 NCBI