RNF122 - ring finger protein 122 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79845

About RNF122

This gene has 1 transcript (splice variant), 234 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 7.2), adrenal (RPKM 6.8) and 25 other tissues.

Summary

The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013]

RNF122 Products (1)

mRNA Protein Name
NM_024787.3 NP_079063.2 RING finger protein 122

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20553626 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
20553626 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of mitochondrial membrane potential IDA
IDA: Inferred from direct assay
16751333 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
16751333 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
20553626 GOA
involved in protein autoubiquitination IMP
IMP: Inferred from mutant phenotype
20553626 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20553626 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF122 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (92 - 133)

  • 0
  • 100
  • 155 a.a.
Protein Preferred Names Protein Names

RING finger protein 122

RNF122 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF122 Q9H9V4 PLLP Homo sapiens Q9Y342
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12042 RNF122 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RNF122 MGD MGI:1916117
Macaca mulatta RNF122 VGNC VGNC:76789
Rattus norvegicus RNF122 RGD RGD:1561238
Canis familiaris RNF122 VGNC VGNC:49772
Felis catus RNF122 VGNC VGNC:64666
Bos taurus RNF122 VGNC VGNC:34015
Others RNF122 NCBI