UPK1B - uroplakin 1B Gene

Also Known as UPIB; UPK1; TSPAN20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7348

About UPK1B

Cytogenetic location: 3q13.32 Genomic coordinates (GRCh38): 3:119,173,598-119,205,143 (from NCBI)

This gene has 5 transcripts (splice variants), 136 orthologues and 32 paralogues. Biased expression in urinary bladder (RPKM 15.8), stomach (RPKM 12.4) and 5 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with Other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

UPK1B Products (1)

mRNA	Protein	Name
NM_006952.4	NP_008883.2	uroplakin-1b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in epithelial cell differentiation	IDA IDA: Inferred from direct assay	10514386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UPK1B Protein Structure

Tetraspannin

0
100
200
260 a.a.

Protein Preferred Names	Protein Names
uroplakin-1b	UP1b

UPK1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UPK1B	O75841	PIK3IP1	Homo sapiens	Q96FE7	Y2H Array	32296183
Intra	UPK1B	O75841	PIK3IP1	Homo sapiens	Q96FE7	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	PIK3IP1	Homo sapiens	Q96FE7	Validated Y2H	32296183
Intra	UPK1B	O75841	PLPP4	Homo sapiens	Q5VZY2	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	PLPP4	Homo sapiens	Q5VZY2	Validated Y2H	32296183
Intra	UPK1B	O75841	PLPP4	Homo sapiens	Q5VZY2	Y2H Array	32296183
Intra	UPK1B	O75841	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	UPK1B	O75841	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	UPK1B	O75841	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	UPK1B	O75841	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	UPK1B	O75841	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	UPK1B	O75841	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	UPK1B	O75841	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	UPK1B	O75841	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	KCNJ6	Homo sapiens	P48051	Validated Y2H	32296183
Intra	UPK1B	O75841	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	UPK1B	O75841	SPINT1	Homo sapiens	O43278-2	Y2H Array	32296183
Intra	UPK1B	O75841	SPINT1	Homo sapiens	O43278-2	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	UPK1B	O75841	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	UPK1B	O75841	ISLR2	Homo sapiens	Q6UXK2	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	ISLR2	Homo sapiens	Q6UXK2	Validated Y2H	32296183
Intra	UPK1B	O75841	ISLR2	Homo sapiens	Q6UXK2	Y2H Array	32296183
Intra	UPK1B	O75841	DAGLA	Homo sapiens	Q9Y4D2	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	DAGLA	Homo sapiens	Q9Y4D2	Validated Y2H	32296183
Intra	UPK1B	O75841	DAGLA	Homo sapiens	Q9Y4D2	Y2H Array	32296183
Intra	UPK1B	O75841	MS4A4A	Homo sapiens	Q96JQ5	Validated Y2H	32296183
Intra	UPK1B	O75841	MS4A4A	Homo sapiens	Q96JQ5	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	MS4A4A	Homo sapiens	Q96JQ5	Y2H Array	32296183
Intra	UPK1B	O75841	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	UPK1B	O75841	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	UPK1B	O75841	EDAR	Homo sapiens	Q9UNE0-2	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	EDAR	Homo sapiens	Q9UNE0-2	Validated Y2H	32296183
Intra	UPK1B	O75841	EDAR	Homo sapiens	Q9UNE0-2	Y2H Array	32296183
Intra	UPK1B	O75841	TMEM91	Homo sapiens	Q6ZNR0-2	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	TMEM91	Homo sapiens	Q6ZNR0-2	Y2H Array	32296183
Intra	UPK1B	O75841	TMEM91	Homo sapiens	Q6ZNR0-2	Validated Y2H	32296183
Intra	UPK1B	O75841	RHCG	Homo sapiens	Q9UBD6	Validated Y2H	32296183
Intra	UPK1B	O75841	RHCG	Homo sapiens	Q9UBD6	Y2H Array	32296183
Intra	UPK1B	O75841	RHCG	Homo sapiens	Q9UBD6	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SDHAF4	Homo sapiens	Q5VUM1	Y2H Array	32296183
Intra	UPK1B	O75841	SDHAF4	Homo sapiens	Q5VUM1	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SDHAF4	Homo sapiens	Q5VUM1	Validated Y2H	32296183
Intra	UPK1B	O75841	TMEM262	Homo sapiens	E9PQX1	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	TMEM262	Homo sapiens	E9PQX1	Y2H Array	32296183
Intra	UPK1B	O75841	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	UPK1B	O75841	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	UPK1B	O75841	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	UPK1B	O75841	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	UPK1B	O75841	GJA8	Homo sapiens	P48165	Validated Y2H	32296183
Intra	UPK1B	O75841	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	UPK1B	O75841	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	GJB1	Homo sapiens	P08034	Validated Y2H	32296183
Intra	UPK1B	O75841	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	UPK1B	O75841	SHISA4	Homo sapiens	Q96DD7	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SHISA4	Homo sapiens	Q96DD7	Validated Y2H	32296183
Intra	UPK1B	O75841	SHISA4	Homo sapiens	Q96DD7	Y2H Array	32296183
Intra	UPK1B	O75841	SLC10A2	Homo sapiens	Q12908	Y2H Array	32296183
Intra	UPK1B	O75841	SLC10A2	Homo sapiens	Q12908	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SLC10A2	Homo sapiens	Q12908	Validated Y2H	32296183
Intra	UPK1B	O75841	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	UPK1B	O75841	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	UPK1B	O75841	VSIG1	Homo sapiens	Q86XK7	Validated Y2H	32296183
Intra	UPK1B	O75841	VSIG1	Homo sapiens	Q86XK7	Y2H Array	32296183
Intra	UPK1B	O75841	VSIG1	Homo sapiens	Q86XK7	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SYT9	Homo sapiens	Q86SS6	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SYT9	Homo sapiens	Q86SS6	Validated Y2H	32296183
Intra	UPK1B	O75841	SYT9	Homo sapiens	Q86SS6	Y2H Array	32296183
Intra	UPK1B	O75841	BEST2	Homo sapiens	Q8NFU1	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	BEST2	Homo sapiens	Q8NFU1	Y2H Array	32296183
Intra	UPK1B	O75841	BEST2	Homo sapiens	Q8NFU1	Validated Y2H	32296183
Intra	UPK1B	O75841	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	UPK1B	O75841	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	UPK1B	O75841	TMUB2	Homo sapiens	Q71RG4	Y2H Array	32296183
Intra	UPK1B	O75841	TMUB2	Homo sapiens	Q71RG4	Validated Y2H	32296183
Intra	UPK1B	O75841	TMUB2	Homo sapiens	Q71RG4	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	UPK1B	O75841	CD69	Homo sapiens	Q07108	Y2H Array	32296183
Intra	UPK1B	O75841	CD69	Homo sapiens	Q07108	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	CD69	Homo sapiens	Q07108	Validated Y2H	32296183
Intra	UPK1B	O75841	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	UPK1B	O75841	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	ITGB2	Homo sapiens	P05107	Validated Y2H	32296183
Intra	UPK1B	O75841	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	UPK1B	O75841	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	UPK1B	O75841	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	UPK1B	O75841	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	UPK1B	O75841	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	TMEM54	Homo sapiens	Q969K7	Validated Y2H	32296183
Intra	UPK1B	O75841	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	UPK1B	O75841	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	UPK1B	O75841	GPR161	Homo sapiens	Q8N6U8	Validated Y2H	32296183
Intra	UPK1B	O75841	GPR161	Homo sapiens	Q8N6U8	Y2H Array	32296183
Intra	UPK1B	O75841	GPR161	Homo sapiens	Q8N6U8	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	CD53	Homo sapiens	P19397	Validated Y2H	32296183
Intra	UPK1B	O75841	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	UPK1B	O75841	SIT1	Homo sapiens	Q9Y3P8	Y2H Array	32296183
Intra	UPK1B	O75841	SIT1	Homo sapiens	Q9Y3P8	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	SIT1	Homo sapiens	Q9Y3P8	Validated Y2H	32296183
Intra	UPK1B	O75841	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	UPK1B	O75841	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	UPK1B	O75841	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	UPK1B	O75841	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	UPK1B	O75841	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	UPK1B	O75841	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	UPK1B	O75841	CLDN7	Homo sapiens	O95471	Validated Y2H	32296183
Intra	UPK1B	O75841	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	UPK1B	O75841	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	UPK1B	O75841	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	UPK1B	O75841	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	UPK1B	O75841	KIR2DL3	Homo sapiens	P43628	Validated Y2H	32296183
Intra	UPK1B	O75841	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	UPK1B	O75841	KLRC1	Homo sapiens	P26715	Validated Y2H	32296183
Intra	UPK1B	O75841	KLRC1	Homo sapiens	P26715	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Marginal Corneal Ulcer
Fraser Syndrome 1	Fraser Syndrome Cryptophthalmos With Other Malformations Cryptophthalmos Syndrome FRASRS1 Cryptophthalmos-Syndactyly Syndrome Fraser-Francois Syndrome Cyclopism Meyer-Schwickerath'S Syndrome Ulrich-Feichtiger Syndrome Cryptophthalmos Syndactyly Syndrome Fraser'S Syndrome Meyer-Schwickerath Syndrome Ullrich-Feichtiger Syndrome
Interstitial Cystitis	Bladder Pain Syndrome Painful Bladder Syndrome Ulcerative Cystitis Ic/Bps Ic/Pbs Interstitial Cystitis/Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome Cystitis, Interstitial Chronic Interstitial Cystitis Pelvic Congestion Syndrome Trigonitis
Cranioectodermal Dysplasia 1	Sensenbrenner Syndrome CED1 Levin Syndrome I Cranio-Ectodermal Dysplasia Dysplasia, Cranioectodermal, Type 1 Cranioectodermal Dysplasia
Bladder Neck Obstruction	Obstruction Of Bladder Neck Or Vesicourethral Orifice Urinary Bladder Neck Obstruction Bladder Outlet Obstruction Vesicourethral Orifice Obstruction Bno - [Bladder Neck Obstruction] Bladder Obstruction Nos Acquired Bladder Neck Obstruction Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice Bladder Neck Strangulation Bladder Neck Stricture Bladder Outflow Obstruction Contracture Of Bladder Neck Or Sphincter Contracture Of Bladder Neck Obstructed Vesicourethral Orifice Strangulation Of Vesicourethral Orifice Stricture Of Vesicourethral Orifice Urinary Prostatic Valve Obstruction Vesical Obstruction
Vesicoureteral Reflux	Vesico-Ureteral Reflux
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15486	UPK1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992310	Anti-UPK-1B Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UPK1B	RGD	RGD:1307806
Mus musculus	UPK1B	MGD	MGI:98912
Bos taurus	UPK1B	VGNC	VGNC:36685
Macaca mulatta	UPK1B	VGNC	VGNC:110320
Canis familiaris	UPK1B	VGNC	VGNC:48155
Felis catus	UPK1B	VGNC	VGNC:66843
Others	UPK1B	NCBI