GPR161 - G protein-coupled receptor 161 Gene

Also Known as RE2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23432

About GPR161

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,079,542-168,137,667 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues, 25 paralogues and is associated with 1 phenotype. Broad expression in endometrium (RPKM 8.0), esophagus (RPKM 3.6) and 20 other tissues.

Summary

The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast Cancer, and disruption of this gene slows the proliferation of basal breast Cancer cells. Therefore, this gene is a potential drug target for triple-negative breast Cancer. [provided by RefSeq, Mar 2017]

GPR161 Products (15)

mRNA	Protein	Name
NM_001267609.1	NP_001254538.1	G-protein coupled receptor 161 isoform 1
NM_001267610.2	NP_001254539.1	G-protein coupled receptor 161 isoform 2
NM_001267611.1	NP_001254540.1	G-protein coupled receptor 161 isoform 3
NM_001267612.2	NP_001254541.1	G-protein coupled receptor 161 isoform 4
NM_001267613.1	NP_001254542.1	G-protein coupled receptor 161 isoform 5
NM_001267614.1	NP_001254543.1	G-protein coupled receptor 161 isoform 6
NM_001349632.1	NP_001336561.1	G-protein coupled receptor 161 isoform 2
NM_001349633.1	NP_001336562.1	G-protein coupled receptor 161 isoform 2
NM_001349634.1	NP_001336563.1	G-protein coupled receptor 161 isoform 2
NM_001349635.1	NP_001336564.1	G-protein coupled receptor 161 isoform 4
NM_001375883.1	NP_001362812.1	G-protein coupled receptor 161 isoform 2
NM_001375884.1	NP_001362813.1	G-protein coupled receptor 161 isoform 2
NM_001375885.1	NP_001362814.1	G-protein coupled receptor 161 isoform 2
NM_001381909.1	NP_001368838.1	G-protein coupled receptor 161 isoform 2
NM_153832.3	NP_722561.1	G-protein coupled receptor 161 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR161 Protein Structure

7tm_1

0
100
200
300
400
500
529 a.a.

Protein Preferred Names	Protein Names
G-protein coupled receptor 161	G-protein coupled receptor RE2

GPR161 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GPR161	Q8N6U8	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GPR161 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89665	GPR161 Antibody (YA9009)	WB, IP, ELISA	human

Related Diseases

Diseases	Alias
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Pituitary Stalk Interruption Syndrome	Ectopic Neurohypophysis Psis
Pituitary Adenoma 2, Growth Hormone-Secreting	PITA2 Acromegaly Due To Pituitary Adenoma 2 Acromegaly, X-Linked Growth Hormone Secreting Pituitary Adenoma 2 Pituitary Adenoma, Growth Hormone-Secreting, 2 Pituitary Adenoma 2, Gh-Secreting Gh-Secreting Pituitary Adenoma 2 X-Linked Acromegaly Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
Alstrom Syndrome	ALMS Alström Syndrome Alss Alstrom-Hallgren Syndrome Alstroem Syndrome
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Joubert Syndrome 32	JBTS32
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ellis-Van Creveld Syndrome	Chondroectodermal Dysplasia Mesoectodermal Dysplasia EVC Ellis Van Creveld Syndrome Mesodermic Dysplasia Ellis-Van Creveld Dysplasia
Meckel Syndrome, Type 1	Meckel-Gruber Syndrome Meckel Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05677	GPR161 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19508	Gpr161 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26002	Gpr161 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPR161	VGNC	VGNC:72991
Bos taurus	GPR161	VGNC	VGNC:29566
Canis familiaris	GPR161	VGNC	VGNC:41412
Rattus norvegicus	GPR161	RGD	RGD:1563245
Mus musculus	GPR161	MGD	MGI:2685054
Felis catus	GPR161	VGNC	VGNC:62684
Others	GPR161	NCBI