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LPCAT2 - lysophosphatidylcholine acyltransferase 2 Gene

Also Known as AYTL1; LPLAT9; AGPAT11; LysoPAFAT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54947

About LPCAT2

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,509,072-55,586,666 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 50.3), bone marrow (RPKM 11.0) and 19 other tissues.

Summary

This gene encodes a member of the lysophospholipid Acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

LPCAT2 Products (1)

mRNA	Protein	Name
NM_017839.5	NP_060309.2	lysophosphatidylcholine acyltransferase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA IDA: Inferred from direct assay	20363836	GOA
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA IDA: Inferred from direct assay	21498505	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in phosphatidylcholine acyl-chain remodeling	IDA IDA: Inferred from direct assay	21498505	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21498505	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	20363836	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	21498505	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPCAT2 Protein Structure

Acyltransferase

EF-hand_7

0
100
200
300
400
500
544 a.a.

Protein Preferred Names	Protein Names
lysophosphatidylcholine acyltransferase 2	1-AGP acyltransferase 11

LPCAT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LPCAT2	Q7L5N7	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	LPCAT2	Q7L5N7	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	LPCAT2	Q7L5N7	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	LPCAT2	Q7L5N7	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	LPCAT2	Q7L5N7	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	LPCAT2	Q7L5N7	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	LPCAT2	Q7L5N7	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	LPCAT2	Q7L5N7	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	LPCAT2	Q7L5N7	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	LPCAT2	Q7L5N7	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	LPCAT2	Q7L5N7	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	LPCAT2	Q7L5N7	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	LPCAT2	Q7L5N7	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	LPCAT2	Q7L5N7	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	LPCAT2	Q7L5N7	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	LPCAT2	Q7L5N7	RHBDD1	Homo sapiens	Q8TEB9	Validated Y2H	32296183
Intra	LPCAT2	Q7L5N7	RHBDD1	Homo sapiens	Q8TEB9	Y2H Array	32296183
Intra	LPCAT2	Q7L5N7	RHBDD1	Homo sapiens	Q8TEB9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Multicentric Osteolysis, Nodulosis, And Arthropathy	Torg-Winchester Syndrome Torg Syndrome Nao Syndrome MONA Nodulosis-Arthropathy-Osteolysis Syndrome Al-Aqeel Sewairi Syndrome Hereditary Multicentric Osteolysis Osteolysis, Hereditary Multicentric Torg-Winchester Syndrome, Formerly Multicentric Osteolysis Nodulosis And Arthropathy Multicentric Osteolysis, Nodulosis And Arthropathy Osteolysis, Multicentric, Nodulosis, And Arthropathy
Winchester Syndrome	WNCHRS Winchester Disease Winchester-Grossman Syndrome
Scrotal Carcinoma	Carcinoma Of Scrotum Malignant Neoplasm Of Scrotum Neoplasm Of Scrotum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112825	TSI-01	Inhibitor	98.52%	Unkown
HY-RS07765	LPCAT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LPCAT2	RGD	RGD:2325051
Bos taurus	LPCAT2	VGNC	VGNC:30962
Macaca mulatta	LPCAT2	VGNC	VGNC:74365
Felis catus	LPCAT2	VGNC	VGNC:63265
Canis familiaris	LPCAT2	VGNC	VGNC:42749
Mus musculus	LPCAT2	MGD	MGI:3606214
Others	LPCAT2	NCBI