1. PI3K/Akt/mTOR
  2. mTOR
  3. (+)-Usnic acid

(+)-Usnic acid 

Cat. No.: HY-N0656A Purity: >99.0%
Handling Instructions

(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity.

For research use only. We do not sell to patients.

(+)-Usnic acid Chemical Structure

(+)-Usnic acid Chemical Structure

CAS No. : 7562-61-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (+)-Usnic acid:

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Description

(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity[1].

IC50 & Target[1]

mTORC1

 

mTORC2

 

Molecular Weight

344.32

Formula

C₁₈H₁₆O₇

CAS No.

7562-61-0

SMILES

O=C([[email protected]@]1(C)C(OC2=C(C(C)=O)C(O)=C(C)C(O)=C12)=C3)C(C(C)=O)C3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 6.32 mg/mL (18.36 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9043 mL 14.5214 mL 29.0428 mL
5 mM 0.5809 mL 2.9043 mL 5.8085 mL
10 mM 0.2904 mL 1.4521 mL 2.9043 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.63 mg/mL (1.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

(+)-Usnic acidmTORMammalian target of RapamycinInhibitorinhibitorinhibit

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Product Name:
(+)-Usnic acid
Cat. No.:
HY-N0656A
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