1. Anti-infection
    Metabolic Enzyme/Protease
  2. HCV
    HCV Protease

Daclatasvir dihydrochloride (Synonyms: BMS-790052 dihydrochloride)

Cat. No.: HY-10465 Purity: 99.70%
Handling Instructions

BMS-790052 is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture.

For research use only. We do not sell to patients.

Daclatasvir dihydrochloride Chemical Structure

Daclatasvir dihydrochloride Chemical Structure

CAS No. : 1009119-65-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 54 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 80 In-stock
Estimated Time of Arrival: December 31
100 mg USD 90 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Daclatasvir dihydrochloride:

    Daclatasvir dihydrochloride purchased from MCE. Usage Cited in: Open Virol J. 2014 Mar 7;8:1-8.

    The PKR activation block is not unique to CypI, DAAs also prevent the IFN-induced PKR activation in HCV-infected cells. JFH-1-infected Huh7.5.1 cells are treated with or without CypI (cyclosporine A and alisporivir), DAAs (the HCV NS5A inhibitor daclatasvir and the HCV protease inhibitor telaprevir) and an HIV-1 inhibitor (reverse transcriptase inhibitor emtricitabine). Results are representative of 4 independent experiments.

    Daclatasvir dihydrochloride purchased from MCE. Usage Cited in: Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):867-876.

    Simeprevir inhibits DNA damage repair following irradiation. U251, BT474, and HepG2 cells are pretreated with Simeprevir or DMSO and irradiated at a dose of 6 Gy. After 6 hours, prolongation of γH2AX foci is detected in Simeprevir-treated cells along with decreased phosphorylation of DNA-PKcs, indicating impaired nonhomologous end-joining repair.

    Daclatasvir dihydrochloride purchased from MCE. Usage Cited in: Eur J Med Chem. 2018 Jan 1;143:1053-1065.

    GS4.3 cells are treated with 7f (20 μM), or Telaprevir (0.5μM), Sofosbuvir (0.8 μM), Daclatasvir (0.15 μM) or solvent control for 6 days.

    Daclatasvir dihydrochloride purchased from MCE. Usage Cited in: Eur J Med Chem. 2018 Jan 1;143:1053-1065.

    Huh7.5 cells are infected with HCV and simultaneously treated with 7f (10 μM) or DAA (0.04 μM Simeprevir, 0.08 μM Sofosbuvir, or 16 pM Daclatasvir) or 7f plus DAA.

    Daclatasvir dihydrochloride purchased from MCE. Usage Cited in: PLoS Pathog. 2018 Sep 18;14(9):e1007284.

    Polyprotein expression efficiency is determined by Western-Blot using an antibody against NS3 and beta actin as loading control.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    BMS-790052 is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. IC50 Value: 9-50 pM Target: HCV NS5A BMS-790052 has broad genotype coverage and exhibits picomolar in vitro potency against genotypes 1a (EC50 50pm) and 1b (EC50 9pm). BMS-790052 produces a robust decline in HCV RNA (-3.6 logs after 48 hours from a single 100 mg) dosefollowing a single dose in patients chronically infected with HCV genotype 1.

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 56 mg/mL (68.98 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2318 mL 6.1592 mL 12.3183 mL
    5 mM 0.2464 mL 1.2318 mL 2.4637 mL
    10 mM 0.1232 mL 0.6159 mL 1.2318 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    811.80

    Formula

    C₄₀H₅₂Cl₂N₈O₆

    CAS No.

    1009119-65-6

    SMILES

    O=C(N1CCC[[email protected]]1C2=NC=C(C3=CC=C(C4=CC=C(C=C4)C5=CN=C(N5)[[email protected]@H]6CCCN6C([[email protected]](C(C)C)NC(OC)=O)=O)C=C3)N2)[[email protected]](C(C)C)NC(OC)=O.[H]Cl.[H]Cl

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.70%

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    Product Name:
    Daclatasvir dihydrochloride
    Cat. No.:
    HY-10465
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    Daclatasvir dihydrochloride

    Cat. No.: HY-10465