1. Apoptosis
  2. Apoptosis
  3. ICCB280

ICCB280 

Cat. No.: HY-134333 Purity: 98.23%
Handling Instructions

ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets.

For research use only. We do not sell to patients.

ICCB280 Chemical Structure

ICCB280 Chemical Structure

CAS No. : 2041072-41-5

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
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10 mg USD 450 In-stock
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25 mg USD 850 In-stock
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50 mg USD 1350 In-stock
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100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets[1][2].

IC50 & Target

C/EBPα[1]

In Vitro

ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM[1].
ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells[1].
ICCB280 (10 μM; 7 d) induces granulocytic differentiationand and subsequent apoptosis in HL-60 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HL-60 cells
Concentration: 0.1, 0.5, 1, 5, 10, 50 μM
Incubation Time: 48 hours
Result: Induced cell growth arrest, with an IC50 of 8.6 μM.

Western Blot Analysis[1]

Cell Line: HL-60 cells
Concentration: 10 μM
Incubation Time: 2, 4, 6, 8 days
Result: Upregulated the C/EBPα protein on day 4.
Increased the C/EBPε expression on day 6.
No changes in C/EBPβ expression through the 8 days of the experiment.
Molecular Weight

386.40

Formula

C₂₃H₁₈N₂O₄

CAS No.

2041072-41-5

SMILES

O=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (215.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5880 mL 12.9400 mL 25.8799 mL
5 mM 0.5176 mL 2.5880 mL 5.1760 mL
10 mM 0.2588 mL 1.2940 mL 2.5880 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

ICCB280ICCB 280ICCB-280ApoptosisC/EBPαdifferentiationproliferationapoptosisanti-leukemicInhibitorinhibitorinhibit

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Product Name:
ICCB280
Cat. No.:
HY-134333
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