SLC48A1 - solute carrier family 48 member 1 Gene

Also Known as HRG1; HRG-1; hHRG-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55652

Summary

Enables heme binding activity and heme transmembrane transporter activity. Involved in heme transport. Located in endosome membrane; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in brain (RPKM 18.5), thyroid (RPKM 14.7) and 25 other tissues.

SLC48A1 Products (1)

mRNA Protein Name
NM_017842.3 NP_060312.2 heme transporter HRG1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables heme binding IDA
IDA: Inferred from direct assay
18418376 GOA
enables heme transmembrane transporter activity IDA
IDA: Inferred from direct assay
18418376 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in heme transport IDA
IDA: Inferred from direct assay
18418376 GOA
acts upstream of or within heme transport IMP
IMP: Inferred from mutant phenotype
23395172 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in endosome membrane IDA
IDA: Inferred from direct assay
18418376 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
18418376 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18418376 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC48A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SLC48A1 Q6P1K1 UNC93A Homo sapiens Q86WB7-2
Y2H Prey Pooling
32296183
Intra
SLC48A1 Q6P1K1 UNC93A Homo sapiens Q86WB7-2
Validated Y2H
32296183
Intra
SLC48A1 Q6P1K1 LAMP1 Homo sapiens P11279
Y2H Prey Pooling
32296183
Intra
SLC48A1 Q6P1K1 LAMP1 Homo sapiens P11279
Y2H Array
32296183
Intra
SLC48A1 Q6P1K1 COMT Homo sapiens P21964
Y2H Array
32296183
Intra
SLC48A1 Q6P1K1 COMT Homo sapiens P21964
Y2H Prey Pooling
32296183
Intra
SLC48A1 Q6P1K1 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
SLC48A1 Q6P1K1 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
SLC48A1 Q6P1K1 LDAF1 Homo sapiens Q96B96
Validated Y2H
32296183
Intra
SLC48A1 Q6P1K1 LDAF1 Homo sapiens Q96B96
Y2H Prey Pooling
32296183
Intra
SLC48A1 Q6P1K1 LDAF1 Homo sapiens Q96B96
Y2H Array
32296183
Intra
SLC48A1 Q6P1K1 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
SLC48A1 Q6P1K1 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
SLC48A1 Q6P1K1 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (22)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS13043 SLC18A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13243 SLC40A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13251 SLC44A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13150 SLC28A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13217 SLC38A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13244 Slc40a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13245 SLC40A1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13246 SLC41A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13248 SLC43A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13256 SLC45A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13260 SLC46A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13263 SLC47A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13265 SLC4A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13337 SLC8A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20193 Slc4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20218 Slc38a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20647 Slc44a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20648 Slc47a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26698 Slc4a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26725 Slc38a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27158 Slc44a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27159 Slc47a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown