Garcinia cambogia extract

C57BL/6J (7-week-old male, high-fat diet-induced obesity model)^[1]

10 g/kg diet (extract contained 60% hydroxycitric acid)

dietary incorporation; ad libitum daily; 12 weeks

Reduced final body weight by 22% and 12-week body weight gain by 46% compared to HFD-fed controls.
Reduced food intake and food efficiency ratio significantly compared to HFD-fed controls.
Reduced total visceral fat depot weight by 39% compared to HFD-fed controls; epididymal, perirenal, retroperitoneal, and mesenteric fat pad weights were reduced by 37%, 48%, 36%, and 42% respectively.
Reduced mean epididymal adipocyte surface area by 34% compared to HFD-fed controls.
Reduced plasma total cholesterol by 24% and plasma triglycerides by 25% compared to HFD-fed controls.
Reduced liver weight by 18%, hepatic triglyceride levels by 14%, and hepatic cholesterol levels by 15% compared to HFD-fed controls.
Reduced plasma insulin levels by 43% and plasma leptin levels by 52% compared to HFD-fed controls.
Increased aP2 mRNA by 120%, SREBP1c mRNA by 12%, C/EBPα mRNA by 174%, and PPARγ2 mRNA by 70% in epididymal fat tissue compared to HFD-fed controls.
Decreased TNFα mRNA by 20% in epididymal fat tissue compared to HFD-fed controls.