2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. FABP PPAR
  4. Garcinia cambogia extract

Garcinia cambogia extract is an orally active anti-obesity agent. Garcinia cambogia extract upregulates the gene expression of aP2, SREBP1c, PPARγ2 and C/EBPα. Garcinia cambogia extract reduces the rate of body weight gain, visceral fat accumulation, lipid levels in blood and liver, as well as plasma insulin and leptin levels. Garcinia cambogia extract ameliorates high-fat diet-induced obesity.

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Garcinia cambogia extract

Garcinia cambogia extract Chemical Structure

CAS No. : 90045-23-1

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Description

Garcinia cambogia extract is an orally active anti-obesity agent[1]. Garcinia cambogia extract upregulates the gene expression of aP2, SREBP1c, PPARγ2 and C/EBPα. Garcinia cambogia extract reduces the rate of body weight gain, visceral fat accumulation, lipid levels in blood and liver, as well as plasma insulin and leptin levels[1][2]. Garcinia cambogia extract ameliorates high-fat diet-induced obesity[1][2].

IC50 & Target[1]

PPARγ2

 

aP2

 

In Vivo

Garcinia cambogia extract (10000 ppm; dietary incorporation; ad libitum daily; 12 weeks) reduces HFD-induced obesity in male C57BL/6J mice by decreasing body weight gain, visceral adiposity, and dyslipidemia, and normalizing adipogenesis-related gene expression in visceral fat tissue[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (7-week-old male, high-fat diet-induced obesity model)[1]
Dosage: 10 g/kg diet (extract contained 60% hydroxycitric acid)
Administration: dietary incorporation; ad libitum daily; 12 weeks
Result: Reduced final body weight by 22% and 12-week body weight gain by 46% compared to HFD-fed controls.
Reduced food intake and food efficiency ratio significantly compared to HFD-fed controls.
Reduced total visceral fat depot weight by 39% compared to HFD-fed controls; epididymal, perirenal, retroperitoneal, and mesenteric fat pad weights were reduced by 37%, 48%, 36%, and 42% respectively.
Reduced mean epididymal adipocyte surface area by 34% compared to HFD-fed controls.
Reduced plasma total cholesterol by 24% and plasma triglycerides by 25% compared to HFD-fed controls.
Reduced liver weight by 18%, hepatic triglyceride levels by 14%, and hepatic cholesterol levels by 15% compared to HFD-fed controls.
Reduced plasma insulin levels by 43% and plasma leptin levels by 52% compared to HFD-fed controls.
Increased aP2 mRNA by 120%, SREBP1c mRNA by 12%, C/EBPα mRNA by 174%, and PPARγ2 mRNA by 70% in epididymal fat tissue compared to HFD-fed controls.
Decreased TNFα mRNA by 20% in epididymal fat tissue compared to HFD-fed controls.
CAS No.
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Solid

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Off-white to light yellow

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[Garcinia cambogia extract]
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Room temperature in continental US; may vary elsewhere.
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Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
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H2O : 20 mg/mL (Need ultrasonic)

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Garcinia cambogia extract90045-23-1FABPPPARFatty acid-binding proteinPeroxisome proliferator-activated receptorsaP2fatty acid synthesisPPARγ2cholesterolSREBP1cC/EBPαtriglycerideTNFαATP-citrate lyaseacetyl-CoAInhibitorinhibitorinhibit

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