2. Metabolic Enzyme/Protease Epigenetics
  3. Endogenous Metabolite Histone Demethylase
  4. Eicosapentaenoic acid metformin

Eicosapentaenoic acid metformin  (Synonyms: EPA metformin; Timnodonic acid metformin)

Cat. No.: HY-B0660A
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Eicosapentaenoic Acid (EPA) metformin is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic acid metformin exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). EEicosapentaenoic acid metformin activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic acid metformin can promote relaxation of vascular smooth muscle cells and vasodilation.

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CAS No. : 1384526-74-2

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30 Publications Citing Use of MCE Eicosapentaenoic acid metformin

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    Eicosapentaenoic acid metformin purchased from MedChemExpress. Usage Cited in: Science. 2025 Mar 14;387(6739):eadm9805.  [Abstract]

    Immunoblot analysis of HCC1806 cells following 16 hour serum starvation and subsequent stimulation with 10% FBS or 30 μM ω-6 LA or Arachidonic acid (AA), or ω-3 ALA, Eicosapentaenoic acid (EPA) or Docosahexaenoic acid (DHA) for 30 minutes.

    Eicosapentaenoic acid metformin purchased from MedChemExpress. Usage Cited in: Science. 2025 Mar 14;387(6739):eadm9805.  [Abstract]

    HCC1806 cells were serum starved for 16 hours and subsequently restimulated for 30 minutes with 1μM, 5μM, 10μM, 30μM, 100μM, 200μM, 1000μM of ω-6 LA, ω-6 ARA, ω-3 ALA, ω-3 EPA and ω-3 DHA for 30 minutes. Intracellular concentrations of each PUFA were quantified by ELISA from lysates obtained from 5 x 106 cells.

    Eicosapentaenoic acid metformin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528.  [Abstract]

    OVCAR8 and A2780 cells were cultured in fatty acid-free media supplemented with 50 μM AA (Arachidonic acid), 50 μM OA (Oleic acid), 50 μM EPA (Eicosapentaenoic acid), 50 μM PA (Palmitic acid), and 50 μM MA (Myristic acid) with the treatment of 10 μM Niraparib for 72 h, and the cell viability was determined.

    Eicosapentaenoic acid metformin purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 May 17:107214.  [Abstract]

    Eicosapentaenoic acid (EPA; 150 mg/kg; oral). Behavioral tests for the forced swim test.

    Eicosapentaenoic acid metformin purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118.  [Abstract]

    Western blot analysis showing the protein levels of HIF-1A, COL1A1, and α-SMA in HSFs treated with 5-20 μM DHA/EPA and under 21% (normoxic) or 5% (hypoxic) oxygen levels.

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    Description

    Eicosapentaenoic Acid (EPA) metformin is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic acid metformin exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). EEicosapentaenoic acid metformin activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic acid metformin can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].

    Molecular Weight

    431.61

    Formula

    C24H41N5O2
    CAS No.
    SMILES

    N=C(N)NC(N(C)C)=N.CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Eicosapentaenoic acid metformin Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Eicosapentaenoic acid metformin1384526-74-2EPA metformin Timnodonic acid metforminEndogenous MetaboliteHistone Demethylaselong-chain polyunsaturated fatty acidω-3 LC-PUFADNA demethylatingCCAATC/EBPδRASERKC/EBPβH-Ras intron 1 CpG islandInhibitorinhibitorinhibit

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