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Eicosapentaenoic acid metformin

(Synonyms: EPA metformin; Timnodonic acid metformin)
32 Cited Publications
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Based on 32 publication(s) in Google Scholar

Eicosapentaenoic Acid (EPA) metformin is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic acid metformin exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). EEicosapentaenoic acid metformin activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic acid metformin can promote relaxation of vascular smooth muscle cells and vasodilation.

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  • CAS No.: 1384526-74-2
  • Formula: C24H41N5O2
  • Molecular Weight:431.61
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Eicosapentaenoic acid metformin Chemical Structure
    Eicosapentaenoic acid metformin Chemical Structure
  • Experimental Validation Results for Eicosapentaenoic acid metformin
  • Experimental Validation Results for Eicosapentaenoic acid metformin
  • Experimental Validation Results for Eicosapentaenoic acid metformin
  • Experimental Validation Results for Eicosapentaenoic acid metformin
  • Experimental Validation Results for Eicosapentaenoic acid metformin
CAS No.: 1384526-74-2
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  • Eicosapentaenoic acid metformin Chemical Structure
    Eicosapentaenoic acid metformin Chemical Structure
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    Eicosapentaenoic acid metformin purchased from MedChemExpress. Usage Cited in: Science. 2025 Mar 14;387(6739):eadm9805. [Abstract]

    Customer Validation
     Immunoblot analysis of HCC1806 cells following 16 hour serum starvation and subsequent stimulation with 10% FBS or 30 μM ω-6 LA or Arachidonic acid (AA), or ω-3 ALA, Eicosapentaenoic acid (EPA) or Docosahexaenoic acid (DHA) for 30 minutes.

  • 1/16

    Eicosapentaenoic acid metformin purchased from MedChemExpress. Usage Cited in: Science. 2025 Mar 14;387(6739):eadm9805. [Abstract]

    Customer Validation
     HCC1806 cells were serum starved for 16 hours and subsequently restimulated for 30 minutes with 1μM, 5μM, 10μM, 30μM, 100μM, 200μM, 1000μM of ω-6 LA, ω-6 ARA, ω-3 ALA, ω-3 EPA and ω-3 DHA for 30 minutes. Intracellular concentrations of each PUFA were quantified by ELISA from lysates obtained from 5 x 106 cells.

  • 1/16

    Eicosapentaenoic acid metformin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Mar:80:103528. [Abstract]

    Customer Validation
     OVCAR8 and A2780 cells were cultured in fatty acid-free media supplemented with 50 μM AA (Arachidonic acid), 50 μM OA (Oleic acid), 50 μM EPA (Eicosapentaenoic acid), 50 μM PA (Palmitic acid), and 50 μM MA (Myristic acid) with the treatment of 10 μM Niraparib for 72 h, and the cell viability was determined.

  • 1/16

    Eicosapentaenoic acid metformin purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 Jun:204:107214. [Abstract]

    Customer Validation
     Eicosapentaenoic acid (EPA; 150 mg/kg; oral). Behavioral tests for the forced swim test.

  • 1/16

    Eicosapentaenoic acid metformin purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118. [Abstract]

    Customer Validation
     Western blot analysis showing the protein levels of HIF-1A, COL1A1, and α-SMA in HSFs treated with 5-20 μM DHA/EPA and under 21% (normoxic) or 5% (hypoxic) oxygen levels.

  • Eicosapentaenoic acid metformin