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BiP inducer X 

Cat. No.: HY-110188 Purity: 99.88%
Handling Instructions

BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress.

For research use only. We do not sell to patients.

BiP inducer X Chemical Structure

BiP inducer X Chemical Structure

CAS No. : 101714-41-4

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5 mg USD 50 In-stock
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10 mg USD 80 In-stock
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100 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress[1][2].

In Vitro

BiP inducer X (5 μM; 0-12 hours; SK-N-SH cells) increase BiP protein[1].
The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1].
BiP inducer X (5 μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BiP inducer X administration reduces the insults due to cerebral infarction[1].
A 20 μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult ddY mice weighing 24-34 g (Japan SLC)[1]
Dosage: 20 μg (2 μl)
Administration: Intracerebroventricularly
Result: Significantly increased the level of BiP protein 24 h after administration, confirming that administration of BIX induces BiP protein in vivo.
Molecular Weight

209.22

Formula

C₉H₇NO₃S

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (238.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7797 mL 23.8983 mL 47.7966 mL
5 mM 0.9559 mL 4.7797 mL 9.5593 mL
10 mM 0.4780 mL 2.3898 mL 4.7797 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
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BiP inducer X
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HY-110188
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