2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Cytoskeleton Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Apoptosis
  3. Reactive Oxygen Species (ROS) MMP Collagen PPAR DNA/RNA Synthesis Apoptosis Caspase
  4. Porphyra 334

Porphyra 334 is a carnosine-like amino acid and a natural photoprotective agent and antioxidant. Porphyra-334 exerts its photoprotective effects by scavenging ROS, inhibiting the expression and activity of MMP-1/8, and promoting the synthesis of collagen and elastin. Porphyra 334 effectively inhibits linoleic acid oxidation induced by alkyl radicals (AAPH) and singlet oxygen. Porphyra 334 has anti-obesity potential by inhibiting the expression of PPARγ2 and C/EBPα. Porphyra 334 protects cells against UV-induced DNA damage and apoptosis by inhibiting the activation of caspase-3.

For research use only. We do not sell to patients.

Porphyra 334

Porphyra 334 Chemical Structure

CAS No. : 70579-26-9

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Porphyra 334 Related Antibodies

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Porphyra 334 is a carnosine-like amino acid and a natural photoprotective agent and antioxidant. Porphyra-334 exerts its photoprotective effects by scavenging ROS, inhibiting the expression and activity of MMP-1/8, and promoting the synthesis of collagen and elastin. Porphyra 334 effectively inhibits linoleic acid oxidation induced by alkyl radicals (AAPH) and singlet oxygen. Porphyra 334 has anti-obesity potential by inhibiting the expression of PPARγ2 and C/EBPα. Porphyra 334 protects cells against UV-induced DNA damage and apoptosis by inhibiting the activation of caspase-3[1][2][3][4].

IC50 & Target[1][3][2]

PPARγ2

 

MMP-1

 

MMP-8

 

Caspase 3

 

In Vitro

Porphyra-334 (6.25-200 μM; 24 h) shows no cytotoxicity against 3T3-L1 preadipocytes at the highest concentration of 200 μM[1].
Porphyra-334 (0.1-1.0 μM) inhibits lipid droplet accumulation in mature 3T3-L1 adipocytes in a dose-dependent manner[1].
Porphyra-334 (0.1-1.0 μM; 5 days) dose-dependently and significantly reduces the mRNA expression levels of PPARγ2, C/EBPα, adiponectin, and leptin in 3T3-L1 cells[1].
Porphyra-334 (0.1 mg/mL; 24-96 h) restores cell proliferation to approximately 88% of that in the unirradiated control group by reducing caspase-3 activation, DNA fragmentation, and the number of apoptotic cells, thereby alleviating UV-induced apoptosis in HaCaT cells[2].
Porphyra 334 (10-40 μM; 24 h) protects human skin fibroblasts (CCD-986sk) exposed to long-wave ultraviolet (UVA) radiation from photoaging by scavenging reactive oxygen species (ROS), inhibiting the expression of MMP-1/MMP-8 and elastase activity, and increasing the levels of procollagen, type I collagen and elastin[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Porphyra 334 Related Antibodies

Cell Viability Assay[1]

Cell Line: 3T3-L1 preadipocytes
Concentration: 6.25, 12.5, 25, 50, 200 μM
Incubation Time: 24 h
Result: Showed no cytotoxic effect on 3T3-L1 cells at concentrations <200 μM, with cell viability comparable to the control group; Observed no morphological changes similar to the control.

Real Time qPCR[1]

Cell Line: 3T3-L1 cells
Concentration: 0.1 and 1.0 μM
Incubation Time: 5 days
Result: Significantly reduced the mRNA expression of peroxisome proliferator-activated receptor γ2 (PPARγ2), CCAAT/enhancer-binding protein α (C/EBPα), adiponectin, and leptin in a dose-dependent manner.
Molecular Weight

346.33

Formula

C14H22N2O8
CAS No.
SMILES

C[C@@H](O)[C@@H](C(O)=O)/N=C1C(OC)=C(C[C@](O)(C/1)CO)NCC(O)=O
Structure Classification
Initial Source

Palythoa tuberculosa
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Porphyra 334 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Porphyra 33470579-26-9Porphyra334Porphyra-334Reactive Oxygen Species (ROS)MMPCollagenPPARDNA/RNA SynthesisApoptosisCaspaseMatrix metalloproteinasesPeroxisome proliferator-activated receptorsCCAAT/enhancer-binding protein alpha (C/EBPα)3T3-L1 cellslaverhuman skin fibroblastsHaCaT cellsperoxisome proliferator-activated receptor gamma 2 (PPARγ2)CCD-986skleptinmatrix metalloproteinase-1 (MMP-1)adiponectin (ADIPOQ)Inhibitorinhibitorinhibit

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