ORMDL2 - ORMDL sphingolipid biosynthesis regulator 2 Gene

Also Known as MST095; HSPC160; MSTP095; adoplin-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29095

Summary

Involved in ceramide metabolic process. Acts upstream of or within negative regulation of ceramide biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in esophagus (RPKM 18.1), colon (RPKM 18.0) and 25 other tissues.

ORMDL2 Products (1)

mRNA Protein Name
NM_014182.5 NP_054901.1 ORM1-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in ceramide metabolic process IMP
IMP: Inferred from mutant phenotype
20182505 GOA
acts upstream of or within negative regulation of ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
25691431 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12093374 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORMDL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ORMDL2 Q53FV1 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
ORMDL2 Q53FV1 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra
ORMDL2 Q53FV1 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
ORMDL2 Q53FV1 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
ORMDL2 Q53FV1 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
ORMDL2 Q53FV1 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
ORMDL2 Q53FV1 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
Intra
ORMDL2 Q53FV1 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
ORMDL2 Q53FV1 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
ORMDL2 Q53FV1 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 TMEM120A Homo sapiens Q9BXJ8
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 TMEM120A Homo sapiens Q9BXJ8
Validated Y2H
32296183
Intra
ORMDL2 Q53FV1 TMEM120A Homo sapiens Q9BXJ8
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
ORMDL2 Q53FV1 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra
ORMDL2 Q53FV1 CYB561 Homo sapiens P49447
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09833 ORMDL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown