1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog
  3. 6-​Thioinosine

6-​Thioinosine (Synonyms: 6TI; 6-Mercaptopurine riboside)

Cat. No.: HY-128671 Purity: 98.12%
Handling Instructions

6-​Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα.

For research use only. We do not sell to patients.

6-​Thioinosine Chemical Structure

6-​Thioinosine Chemical Structure

CAS No. : 574-25-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

6-​Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2].

Molecular Weight

284.29

Formula

C₁₀H₁₂N₄O₄S

CAS No.

574-25-4

SMILES

S=C1NC=NC2=C1N=CN2C3[[email protected]@H]([[email protected]@H]([[email protected]@H](CO)O3)O)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (175.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5175 mL 17.5877 mL 35.1753 mL
5 mM 0.7035 mL 3.5175 mL 7.0351 mL
10 mM 0.3518 mL 1.7588 mL 3.5175 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.12%

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Product Name:
6-​Thioinosine
Cat. No.:
HY-128671
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