574-25-4
574-25-4
Chemical Structure
6-Thioinosine
Synonym(s): 6TI; 6-Mercaptopurine riboside
- No. CAS: 574-25-4
- Formula:C10H12N4O4S
- Molecular Weight:284.30
IUPAC Name: 9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purine-6-thione
InChIKey: NKGPJODWTZCHGF-KQYNXXCUSA-N
SMILES: S=C1NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3
Biological Activity: 6-Thioinosine (6TI) is a purine antimetabolite and an anti-adipogenic agent. 6-Thioinosine reduces the mRNA levels of PPARγ and C/EBPα and downregulates the mRNA levels of PPARγ target genes (LPL, CD36, aP2, and LXRα). 6-Thioinosine exerts its anti-adipogenic effects by downregulating PPARγ through JNK-dependent iNOS upregulation. 6-Thioinosine can be used to study adipocyte dysfunction[1].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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6-Thioinosine | 99.31% | 6-Thioinosine (6TI) is a purine antimetabolite and an anti-adipogenic agent. 6-Thioinosine reduces the mRNA levels of PPARγ and C/EBPα and downregulates the mRNA levels of PPARγ target genes (LPL, CD36, aP2, and LXRα). 6-Thioinosine exerts its anti-adipogenic effects by downregulating PPARγ through JNK-dependent iNOS upregulation. 6-Thioinosine can be used to study adipocyte dysfunction. | ||||||||||||||||||||
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6-Thioguanosine (Standard) | 98.05% | 6-Thioguanosine (Standard) (6-Mercaptoguanosine (Standard)) is the analytical standard of 6-Thioguanosine (HY-119499). This product is intended for research and analytical applications. 6-Thioguanosine (6-Mercaptoguanosine) is a ribonucleoside (nucleotide) metabolite of Azathioprine (HY-B0256). 6-Thioguanosine forms TGTP, which binds to Rac1 GTPase in an inhibitory manner, and is incorporated into newly synthesized RNA, mRNA, large/small RNA, and genomic DNA, with mRNA being the most abundant. 6-Thioguanosine inhibits the methylation of adjacent cytosines at methylated CpG sites, enhances the methylation of contralateral cytosines at unmethylated CpG sites, and inhibits the synthesis of poly (A)-containing RNA. 6-Thioguanosine does not inhibit general protein synthesis, does not cause depolymerization of polyribosomes, does not affect cytoplasmic/nuclear RNA synthesis, and does not affect RNA lacking poly (A) in the cytoplasm. 6-Thioguanosine can be used in research on acute lymphoblastic leukemia. | ||||||||||||||||||||
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L-Inosine | 99.91% | L-Inosine is the L-configuration of Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. | ||||||||||||||||||||
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Inosine-15N4 | 98.40% | Inosine-15N4 is the 15N labeled Inosine. | ||||||||||||||||||||
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1,9-Dihydro-9-β-D-xylofuranosyl-6H-purin-6-one | 1,9-Dihydro-9-β-D-xylofuranosyl-6H-purin-6-one is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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2′-Deoxy-6-thioinosine | 2′-Deoxy-6-thioinosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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Alpha-inosine | Alpha-inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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Adenosine-15N5 | 99.9% | Adenosine-15N5 (Adenine riboside-15N5; D-Adenosine-15N5) is the 15N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation. | ||||||||||||||||||||
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Inosine | 99.94% | Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors. | ||||||||||||||||||||
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Inosine-13C5 | 99.90% | Inosine-13C5 is the 13C5 labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors. | ||||||||||||||||||||
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6-Thioinosine Phosphate | 90.00% | 6-Thioinosine Phosphate (Thioinosinic acid) is an intermediate metabolite of azathioprine (HY-B0256). Azathioprine is a purine analog immunosuppressive drug. | ||||||||||||||||||||
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