574-25-4
Chemical Structure
6-Thioinosine
Synonym(s): 6TI; 6-Mercaptopurine riboside
- CAS No.: 574-25-4
- Formula:C10H12N4O4S
- Molecular Weight:284.30
IUPAC Name: 9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purine-6-thione
InChIKey: NKGPJODWTZCHGF-KQYNXXCUSA-N
SMILES: S=C1NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3
Biological Activity: 6-Thioinosine (6TI) is a purine antimetabolite and an anti-adipogenic agent. 6-Thioinosine reduces the mRNA levels of PPARγ and C/EBPα and downregulates the mRNA levels of PPARγ target genes (LPL, CD36, aP2, and LXRα). 6-Thioinosine exerts its anti-adipogenic effects by downregulating PPARγ through JNK-dependent iNOS upregulation. 6-Thioinosine can be used to study adipocyte dysfunction[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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6-Thioinosine | 99.31% | 6-Thioinosine (6TI) is a purine antimetabolite and an anti-adipogenic agent. 6-Thioinosine reduces the mRNA levels of PPARγ and C/EBPα and downregulates the mRNA levels of PPARγ target genes (LPL, CD36, aP2, and LXRα). 6-Thioinosine exerts its anti-adipogenic effects by downregulating PPARγ through JNK-dependent iNOS upregulation. 6-Thioinosine can be used to study adipocyte dysfunction. | ||||||||||||||||||||
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