SFXN5 - sideroflexin 5 Gene

Also Known as BBG-TCC; SLC56A5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 94097

About SFXN5

Cytogenetic location: 2p13.2 Genomic coordinates (GRCh38): 2:72,942,036-73,071,712 (from NCBI)

This gene has 22 transcripts (splice variants), 252 orthologues and 4 paralogues. Broad expression in brain (RPKM 13.0), liver (RPKM 3.8) and 20 other tissues.

Summary

Predicted to enable citrate transmembrane transporter activity. Predicted to be involved in citrate transport and mitochondrial transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SFXN5 Products (20)

mRNA Protein Name
NM_001330400.2 NP_001317329.1 sideroflexin-5 isoform 1
NM_001330401.2 NP_001317330.1 sideroflexin-5 isoform 3
NM_001330402.2 NP_001317331.1 sideroflexin-5 isoform 4
NM_001330403.2 NP_001317332.1 sideroflexin-5 isoform 5 precursor
NM_001330404.2 NP_001317333.1 sideroflexin-5 isoform 6
NM_001330405.2 NP_001317334.1 sideroflexin-5 isoform 7 precursor
NM_001330406.2 NP_001317335.1 sideroflexin-5 isoform 8 precursor
NM_001330407.2 NP_001317336.1 sideroflexin-5 isoform 9
NM_001330408.2 NP_001317337.1 sideroflexin-5 isoform 10
NM_001330410.2 NP_001317339.1 sideroflexin-5 isoform 6
NM_001330411.2 NP_001317340.1 sideroflexin-5 isoform 11
NM_001330412.2 NP_001317341.1 sideroflexin-5 isoform 11
NM_001371737.1 NP_001358666.1 sideroflexin-5 isoform 12
NM_001371738.1 NP_001358667.1 sideroflexin-5 isoform 13
NM_001371739.1 NP_001358668.1 sideroflexin-5 isoform 14
NM_001371740.1 NP_001358669.1 sideroflexin-5 isoform 15
NM_001371741.1 NP_001358670.1 sideroflexin-5 isoform 16
NM_001371742.1 NP_001358671.1 sideroflexin-5 isoform 17
NM_001371743.1 NP_001358672.1 sideroflexin-5 isoform 18
NM_144579.3 NP_653180.1 sideroflexin-5 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
30442778 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFXN5 Protein Structure

Mtc

Mtc: Tricarboxylate carrier (32 - 340)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

sideroflexin-5

SFXN5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SFXN5 Q8TD22 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
SFXN5 Q8TD22 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
SFXN5 Q8TD22 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
SFXN5 Q8TD22 TMPPE Homo sapiens Q6ZT21
Y2H Array
32296183
Intra
SFXN5 Q8TD22 TMPPE Homo sapiens Q6ZT21
Y2H Prey Pooling
32296183
Intra
SFXN5 Q8TD22 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
SFXN5 Q8TD22 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
SFXN5 Q8TD22 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SFXN5 Q8TD22 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SFXN5 Q8TD22 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
SFXN5 Q8TD22 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
SFXN5 Q8TD22 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
SFXN5 Q8TD22 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
SFXN5 Q8TD22 APOL2 Homo sapiens Q9BQE5
Y2H Array
32296183
Intra
SFXN5 Q8TD22 APOL2 Homo sapiens Q9BQE5
Y2H Prey Pooling
32296183
Intra
SFXN5 Q8TD22 APOL2 Homo sapiens Q9BQE5
Validated Y2H
32296183
Intra
SFXN5 Q8TD22 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SFXN5 Q8TD22 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SFXN5 Q8TD22 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SFXN5 Q8TD22 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
SFXN5 Q8TD22 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
SFXN5 Q8TD22 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 18

  • Growth And Developmental Delay-Hypotonia-Vision Impairment-Lactic Acidosis Syndrome

  • COXPD18

  • Combined Oxidative Phosphorylation Deficiency, Type 18
Parkinson Disease 21

  • PARK21

  • Parkinson'S Disease 21

  • Parkinson Disease, Type 21
Sengers Syndrome

  • Mitochondrial Dna Depletion Syndrome 10

  • Cardiomyopathy And Cataract

  • Cataract And Cardiomyopathy

  • MTDPS10

  • Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome

  • Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10

  • Senger Syndrome
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12789 SFXN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SFXN5 VGNC VGNC:65073
Macaca mulatta SFXN5 VGNC VGNC:77243
Bos taurus SFXN5 VGNC VGNC:34534
Mus musculus SFXN5 MGD MGI:2137681
Rattus norvegicus SFXN5 RGD RGD:628706
Canis familiaris SFXN5 VGNC VGNC:46090
Others SFXN5 NCBI