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Art. -Nr.: HY-N20666

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Canola oil

Canola oil is an orally effective adipogenesis inhibitor and gut microbiota modulator. Canola oil inhibits the expression of PPARγ, SREBP1, SREBP2, Insig1 and Insig2, and increases the phosphorylation level of the AMPK pathway. Canola oil inhibits adipogenesis and reshapes gut microbiota in mice to ameliorate obesity. Canola oil can be used in obesity-related research.

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CAS. Nr.: 120962-03-0

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Canola oil Chemical Structure

CAS. Nr.: 120962-03-0

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Beschreibung

IC₅₀ & Target^[1]

PPARγ

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In Vivo

Canola oil (9 g/kg per day, i.g. 6 weeks) improves high-fat diet-induced obesity in male C57BL/6J mice via mechanisms mediated by Alistipes and the AMPK pathway, which inhibits adipogenesis, restores hepatic lipase activity, remodels the gut microbiota, and enhances acetate production^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 18.095 g, high-fat diet-induced obesity)^[1]
Dosage:

9 g/kg/day
Administration:

i.g.; daily; 6 weeks
Result:

Significantly reduced final body weight and weight gain (p < 0.001).
Reduced the ratio of subcutaneous adipose tissue to body weight.
Significantly increased acetyl-CoA carboxylase activity, and restored hepatic lipase, lipoprotein lipase, and lipase synthase activity to near control levels.
Significantly reduced hepatic mRNA and protein expression of lipogenesis-related genes SREBP1, SREBP2, Insig1, Insig2, PPAR, and PPARγ, and reduced AMPK pathway phosphorylation.
Increased fecal acetic acid concentration and normalized concentrations of valeric acid.
Increased gut microbiota alpha diversity (elevated detected species, chao1, and ACE indexes) and significantly increased the relative abundances of Akkermansia, Dubosiella, and Alistipes genera.
Showed a strong positive correlation between Alistipes abundance and fecal acetic acid levels.

Chemical Information

CAS. Nr. 120962-03-0
SMILES

[Canola oil]
Structure Classification
- Lipids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Gao J, et al.. Canola Oil Ameliorates Obesity by Suppressing Lipogenesis and Reprogramming the Gut Microbiota in Mice via the AMPK Pathway. Nutrients. 2024 Oct 04;16(19):3379. [Content Brief]

[2]. Narine, S.S., Yue, J. & Kong, X. Production of Polyols from Canola Oil and their Chemical Identification and Physical Properties. J Amer Oil Chem Soc 84, 173-179 (2007)

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

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Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vivo
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Canola oil

Alle PPAR Isoform-spezifische Produkte anzeigen

Alle AMPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Canola oil Related Classifications

HY-N20666 Related Classifications