country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N20666

Copy Link Print Information

Canola oil

Canola oil is an orally effective adipogenesis inhibitor and gut microbiota modulator. Canola oil inhibits the expression of PPARγ, SREBP1, SREBP2, Insig1 and Insig2, and increases the phosphorylation level of the AMPK pathway. Canola oil inhibits adipogenesis and reshapes gut microbiota in mice to ameliorate obesity. Canola oil can be used in obesity-related research.

For research use only. We do not sell to patients.

CAS No.: 120962-03-0

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Canola oil Chemical Structure

CAS No.: 120962-03-0

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PPARγ

All PPAR Isoforms :

All AMPK Isoforms :

In Vivo

Canola oil (9 g/kg per day, i.g. 6 weeks) improves high-fat diet-induced obesity in male C57BL/6J mice via mechanisms mediated by Alistipes and the AMPK pathway, which inhibits adipogenesis, restores hepatic lipase activity, remodels the gut microbiota, and enhances acetate production^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 18.095 g, high-fat diet-induced obesity)^[1]
Dosage:

9 g/kg/day
Administration:

i.g.; daily; 6 weeks
Result:

Significantly reduced final body weight and weight gain (p < 0.001).
Reduced the ratio of subcutaneous adipose tissue to body weight.
Significantly increased acetyl-CoA carboxylase activity, and restored hepatic lipase, lipoprotein lipase, and lipase synthase activity to near control levels.
Significantly reduced hepatic mRNA and protein expression of lipogenesis-related genes SREBP1, SREBP2, Insig1, Insig2, PPAR, and PPARγ, and reduced AMPK pathway phosphorylation.
Increased fecal acetic acid concentration and normalized concentrations of valeric acid.
Increased gut microbiota alpha diversity (elevated detected species, chao1, and ACE indexes) and significantly increased the relative abundances of Akkermansia, Dubosiella, and Alistipes genera.
Showed a strong positive correlation between Alistipes abundance and fecal acetic acid levels.

Chemical Information

CAS No. 120962-03-0
SMILES

[Canola oil]
Structure Classification
- Lipids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gao J, et al.. Canola Oil Ameliorates Obesity by Suppressing Lipogenesis and Reprogramming the Gut Microbiota in Mice via the AMPK Pathway. Nutrients. 2024 Oct 04;16(19):3379. [Content Brief]

[2]. Narine, S.S., Yue, J. & Kong, X. Production of Polyols from Canola Oil and their Chemical Identification and Physical Properties. J Amer Oil Chem Soc 84, 173-179 (2007)

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Canola oil

All PPAR Isoforms

All AMPK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Canola oil Related Classifications

HY-N20666 Related Classifications