2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Epigenetics PI3K/Akt/mTOR
  3. PPAR Fatty Acid Synthase (FASN) AMPK
  4. Canola oil

Canola oil is an orally effective adipogenesis inhibitor and gut microbiota modulator. Canola oil inhibits the expression of PPARγ, SREBP1, SREBP2, Insig1 and Insig2, and increases the phosphorylation level of the AMPK pathway. Canola oil inhibits adipogenesis and reshapes gut microbiota in mice to ameliorate obesity. Canola oil can be used in obesity-related research.

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Canola oil

Canola oil Chemical Structure

CAS No. : 120962-03-0

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Canola oil Related Antibodies

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Description

Canola oil is an orally effective adipogenesis inhibitor and gut microbiota modulator. Canola oil inhibits the expression of PPARγ, SREBP1, SREBP2, Insig1 and Insig2, and increases the phosphorylation level of the AMPK pathway. Canola oil inhibits adipogenesis and reshapes gut microbiota in mice to ameliorate obesity. Canola oil can be used in obesity-related research[1].

IC50 & Target[1]

PPARγ

 

In Vivo

Canola oil (9 g/kg per day, i.g. 6 weeks) improves high-fat diet-induced obesity in male C57BL/6J mice via mechanisms mediated by Alistipes and the AMPK pathway, which inhibits adipogenesis, restores hepatic lipase activity, remodels the gut microbiota, and enhances acetate production[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 18.095 g, high-fat diet-induced obesity)[1]
Dosage: 9 g/kg/day
Administration: i.g.; daily; 6 weeks
Result: Significantly reduced final body weight and weight gain (p < 0.001).
Reduced the ratio of subcutaneous adipose tissue to body weight.
Significantly increased acetyl-CoA carboxylase activity, and restored hepatic lipase, lipoprotein lipase, and lipase synthase activity to near control levels.
Significantly reduced hepatic mRNA and protein expression of lipogenesis-related genes SREBP1, SREBP2, Insig1, Insig2, PPAR, and PPARγ, and reduced AMPK pathway phosphorylation.
Increased fecal acetic acid concentration and normalized concentrations of valeric acid.
Increased gut microbiota alpha diversity (elevated detected species, chao1, and ACE indexes) and significantly increased the relative abundances of Akkermansia, Dubosiella, and Alistipes genera.
Showed a strong positive correlation between Alistipes abundance and fecal acetic acid levels.
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[Canola oil]
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Keywords:

Canola oil120962-03-0PPARFatty Acid Synthase (FASN)AMPKPeroxisome proliferator-activated receptorsAMP-activated protein kinaseInsig1SREBP1gut microbiotaAlistipesmale C57BL/6J miceInsig2SREBP2hepatic steatosisPPARγAMPK pathwayInhibitorinhibitorinhibit

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