CCR10
C-C chemokine receptor type 10 (CCR10, GPR2) is a Gαi-coupled receptor that mediates skin and mucosal homing through its ligands CCL27 (CTACK/ALP) and CCL28 (MEC), which are produced by epidermal keratinocytes and mucosal epithelial cells respectively. CCR10 cooperates with CCR4 and the cutaneous lymphocyte antigen to direct memory T cells-particularly cutaneous CD8+ and dermal γδ T-cell subsets-to inflamed and steady-state skin, while CCL28-CCR10 additionally recruits IgA-producing plasmablasts to mucosal surfaces of the gut, lactating mammary gland and salivary glands, linking the receptor to secretory immunity. In the inflamed skin of psoriasis and atopic dermatitis, CCR10+ T cells and keratinocyte CCL27 form a feedback loop amplifying lymphocyte retention. CCR10 is overexpressed in cutaneous T-cell lymphoma, breast cancer and melanoma, facilitating cutaneous and organ metastasis; in HIV pathogenesis, CCL28 exhibits antiviral properties by blocking viral entry. The CCR10-CCL27/28 axis thus integrates barrier-specific lymphocyte trafficking with epithelial homeostasis and disease.
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CCR10 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
