2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Elgemtumab

Elgemtumab  (Synonyms: LJM716)

Cat. No.: HY-P99936 Purity: 96.80%
COA

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Elgemtumab(LJM716) is a fully human IgG monoclonal antibody. Elgemtumab can specifically bind to HER3, block ligand-dependent and independent HER3 signal transduction and cell proliferation, and has good anti-tumor potential.

For research use only. We do not sell to patients.

Elgemtumab Chemical Structure

Elgemtumab Chemical Structure

CAS No. : 1512559-37-3

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1 mg USD 350 In-stock
5 mg USD 910 In-stock
10 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Elgemtumab(LJM716) is a fully human IgG monoclonal antibody. Elgemtumab can specifically bind to HER3, block ligand-dependent and independent HER3 signal transduction and cell proliferation, and has good anti-tumor potential[1].

In Vivo

Elgemtumab(LJM716)(i.v., 20 mg/kg,once) can reduce pHER3 by 52% and pAKT by 84% in SCID mice with BT474 breast cancer xenografts; while in BxPC-3 pancreatic xenografts In SCID mice, it resulted in a maximum inhibition of pHER3 of 86% and a maximum inhibition of pAKT of 74%[1].
Elgemtumab (LJM716) (20 mg/kg, every other day, 35 days) slows tumor growth in NSG mice with BT474 breast cancer xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Elgemtumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 96.80%

COA (231 KB)

Handling Instructions (2659 KB)
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Elgemtumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elgemtumab1512559-37-3LJM716LJM 716LJM-716EGFREpidermal growth factor receptorErbB-1HER1IgG monoclonal antibodyHER3anti-tumorInhibitorinhibitorinhibit

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