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Lumretuzumab

(Synonyms: Anti-Human ERBB3 Recombinant Antibody)
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Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody) is a humanized anti-HER3 (ERBB3) monoclonal antibody. Lumretuzumab effectively inhibits the activity of key oncogenic signaling pathways such as PI3K/AKT and MAPK. Lumretuzumab has been optimized through glycosyl engineering to enhance antibody-dependent cell-mediated cytotoxicity (ADCC). Lumretuzumab can be used to study HER3-positive, HER2-low-expressing solid tumors, especially breast cancer.

For research use only. We do not sell to patients.

  • Purity: ≥99.0%
  • CAS No.: 1448327-63-6
  • Molecular Weight:146.92 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Lumretuzumab
  • Experimental Validation Results for Lumretuzumab
  • Experimental Validation Results for Lumretuzumab
  • Lumretuzumab Chemical Structure
    Lumretuzumab Chemical Structure
CAS No.: 1448327-63-6
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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100 mg

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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized HER3 Protein, Human (HEK293, His, HY-P72625) can bind Lumretuzumab. The EC50 for this effect is 3.513 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with Lumretuzumab (HY-P99304, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Lumretuzumab Chemical Structure
    1/16
  • Lumretuzumab
  • Immobilized HER3 Protein, Human (HEK293, His, HY-P72625) can bind Lumretuzumab. The EC50 for this effect is 3.513 ng/mL.
  • Flow cytometric analysis of 1X106 MCF-7 cells with Lumretuzumab (HY-P99304, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).