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Zenocutuzumab

(Synonyms: MCLA-128; PB4188; R040517)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3.

For research use only. We do not sell to patients.

  • Purity: 99.9%
  • CAS No.: 1969309-56-5
  • Molecular Weight:145.76 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Zenocutuzumab
  • Experimental Validation Results for Zenocutuzumab
  • Experimental Validation Results for Zenocutuzumab
  • Experimental Validation Results for Zenocutuzumab
  • Zenocutuzumab Chemical Structure
    Zenocutuzumab Chemical Structure
CAS No.: 1969309-56-5
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609-228-6898
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with Zenocutuzumab (HY-P99507, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized HER2/CD340 Protein, Human (HEK293, HY-P73094) can bind Zenocutuzumab. The EC50 for this effect is 2.42 ng/mL.

  • 1/16

    Immobilized HER3 Protein, Human (HEK293, His, HY-P72625) can bind Zenocutuzumab. The EC50 for this effect is 31.77 ng/mL.

  • Zenocutuzumab Chemical Structure
    1/16
  • Zenocutuzumab
  • Flow cytometric analysis of 1X106 MCF-7 cells with Zenocutuzumab (HY-P99507, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized HER2/CD340 Protein, Human (HEK293, HY-P73094) can bind Zenocutuzumab. The EC50 for this effect is 2.42 ng/mL.
  • Immobilized HER3 Protein, Human (HEK293, His, HY-P72625) can bind Zenocutuzumab. The EC50 for this effect is 31.77 ng/mL.