2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Zenocutuzumab

Zenocutuzumab  (Synonyms: MCLA-128; PB4188; R040517)

Cat. No.: HY-P99507 Purity: 99.20%
COA

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Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3.

For research use only. We do not sell to patients.

Zenocutuzumab Chemical Structure

Zenocutuzumab Chemical Structure

CAS No. : 1969309-56-5

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5 mg USD 850 In-stock
10 mg USD 1360 In-stock
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Based on 1 publication(s) in Google Scholar

Zenocutuzumab Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3[1].

In Vitro

Zenocutuzumab (0.001-1000 nM; 96 hours) inhibits cell growth in lung and breast cancer cell lines[1].
Zenocutuzumab (0.1-1000 nM; 24 hours) inhibits HER3 and AKT phosphorylation, induces markers of apoptosis and cell cycle arrest in lung and breast cancer cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zenocutuzumab Related Antibodies

Cell Viability Assay[1]

Cell Line: Human bronchiolar epithelial cell lines (HBEC)
Concentration: 0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM
Incubation Time: 96 h
Result: Reduced the growth of isogenic HBEC expressing either CD74-NRG1 or VAMP2-NRG1 fusions.

Western Blot Analysis[1]

Cell Line: HBEC-CD74-NRG1, LUAD-0061AS3, MDA-MB-175-VII cells
Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM
Incubation Time: 24 hours
Result: Inhibited HER3, STAT3, AKT, p70S6K, and S6 phosphorylation.
In Vivo

Zenocutuzumab (2.5-25 mg/kg; i.p.; once weekly; for 28 days) causes a statistically significant reduction of growth, including tumor regression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 to 12-week-old female NSG™ (LUAD-0061AS3), BALB/c nude (OV-10–0050) or athymic nude (ST2891, ST3204 and CTG-0953) mice injected with NRG1 fusion-positive patient-derived xenograft (PDX) tumors[1].
Dosage: 2.5 mg/kg, 8 mg/kg, or 25 mg/kg
Administration: i.p.; once weekly; for 28 days
Result: Blocked growth of lung and ovarian cancer PDX models.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Zenocutuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.20%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Zenocutuzumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zenocutuzumab1969309-56-5MCLA-128 PB4188 R040517MCLA128MCLA 128PB4188PB 4188PB-4188R040517R 040517R-040517EGFREpidermal growth factor receptorErbB-1HER1HER2HER3humanized IgG1 antibodySTAT3AKTp70S6Kand S6 phosphorylationInhibitorinhibitorinhibit

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