SJF-1528
Based on 1 Customer Validation
SJF-1528 (PROTAC 1) is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 also degrades HER2. SJF-1528 promotes ubiquitination and degradation of EGFR and can be used in breast cancer research.
(Pink: EGFR ligand (HY-159047); Blue: VHL ligand (HY-125845); Black: linker (HY-130532)).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.86%
- CAS. Nr.: 2230821-38-0
- Formel: C55H57ClFN7O8S
- Molecular Weight:1030.60
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Speicherung:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Immunology/Inflammation Compound Library
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Anti-Breast Cancer Compound Library
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Angiogenesis-Related Compound Library
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Membrane Protein-targeted Compound Library
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Alle PROTACs Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-BR-3 | IC50 |
102 nM
Compound: 30
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Antiproliferative activity against human SK-BR-3 cells
Antiproliferative activity against human SK-BR-3 cells
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[PMID: 34656901] |
SJF-1528 (24 h) induces EGFR degradation in OVCAR8 cells, with a DC50 of 39.2 nM, and induces degradation of the FLAG-tagged exon 20 insertion mutant EGFR in HeLa cells, with a DC50 of 736.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2230821-38-0
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Appearance Solid
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Molecular Weight 1030.60
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Formel C55H57ClFN7O8S
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Color White to off-white
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SMILES
O=C([C@H]1N(C([C@@H](NC(COCCOCCOC2=CC=C(C3=CC4=C(NC5=CC=C(OCC6=CC=CC(F)=C6)C(Cl)=C5)N=CN=C4C=C3)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Lösungsmittel & Löslichkeit
DMSO : 103.06 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9703 mL | 4.8515 mL | 9.7031 mL | 24.2577 mL |
| 5 mM | 0.1941 mL | 0.9703 mL | 1.9406 mL | 4.8515 mL | |
| 10 mM | 0.0970 mL | 0.4852 mL | 0.9703 mL | 2.4258 mL | |
| 15 mM | 0.0647 mL | 0.3234 mL | 0.6469 mL | 1.6172 mL | |
| 20 mM | 0.0485 mL | 0.2426 mL | 0.4852 mL | 1.2129 mL | |
| 25 mM | 0.0388 mL | 0.1941 mL | 0.3881 mL | 0.9703 mL | |
| 30 mM | 0.0323 mL | 0.1617 mL | 0.3234 mL | 0.8086 mL | |
| 40 mM | 0.0243 mL | 0.1213 mL | 0.2426 mL | 0.6064 mL | |
| 50 mM | 0.0194 mL | 0.0970 mL | 0.1941 mL | 0.4852 mL | |
| 60 mM | 0.0162 mL | 0.0809 mL | 0.1617 mL | 0.4043 mL | |
| 80 mM | 0.0121 mL | 0.0606 mL | 0.1213 mL | 0.3032 mL |
SJF-1528 Related Classifications
HY-131864 Related Classifications
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