SJF-1528 hemihydrate
Based on 1 Customer Validation
SJF-1528 (PROTAC 1) hemihydrate is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 hemihydrate also degrades HER2. SJF-1528 hemihydrate promotes ubiquitination and degradation of EGFR and can be used in breast cancer research.
(Pink: EGFR ligand (HY-159047); Blue: VHL ligand (HY-125845); Black: linker (HY-130532)).
For research use only. We do not sell to patients.
- Purity: 98.90%
- Formula: C55H57ClFN7O8S.1/2H2O
- Molecular Weight:1039.62
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SJF-1528 (24 h) hemihydrate induces EGFR degradation in OVCAR8 cells, with a DC50 of 39.2 nM, and induces degradation of the FLAG-tagged exon 20 insertion mutant EGFR in HeLa cells, with a DC50 of 736.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 1039.62
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Formula C55H57ClFN7O8S.1/2H2O
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Color Off-white to light yellow
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SMILES
O=C([C@H]1N(C([C@@H](NC(COCCOCCOC2=CC=C(C3=CC4=C(NC5=CC=C(OCC6=CC=CC(F)=C6)C(Cl)=C5)N=CN=C4C=C3)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7.[1/2].O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 104 mg/mL (100.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9619 mL | 4.8094 mL | 9.6189 mL | 24.0472 mL |
| 5 mM | 0.1924 mL | 0.9619 mL | 1.9238 mL | 4.8094 mL | |
| 10 mM | 0.0962 mL | 0.4809 mL | 0.9619 mL | 2.4047 mL | |
| 15 mM | 0.0641 mL | 0.3206 mL | 0.6413 mL | 1.6031 mL | |
| 20 mM | 0.0481 mL | 0.2405 mL | 0.4809 mL | 1.2024 mL | |
| 25 mM | 0.0385 mL | 0.1924 mL | 0.3848 mL | 0.9619 mL | |
| 30 mM | 0.0321 mL | 0.1603 mL | 0.3206 mL | 0.8016 mL | |
| 40 mM | 0.0240 mL | 0.1202 mL | 0.2405 mL | 0.6012 mL | |
| 50 mM | 0.0192 mL | 0.0962 mL | 0.1924 mL | 0.4809 mL | |
| 60 mM | 0.0160 mL | 0.0802 mL | 0.1603 mL | 0.4008 mL | |
| 80 mM | 0.0120 mL | 0.0601 mL | 0.1202 mL | 0.3006 mL | |
| 100 mM | 0.0096 mL | 0.0481 mL | 0.0962 mL | 0.2405 mL |
SJF-1528 hemihydrate Related Classifications
HY-131864A Related Classifications
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