SJF-1528 hemihydrate

Name: SJF-1528 hemihydrate
Brand: MedChemExpress
SKU: HY-131864A
Rating: 4.5 (1 reviews)

製品番号: HY-131864A 純度: 98.90%: Data Sheet SDS COA 取扱説明書
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SJF-1528 (PROTAC 1) hemihydrate is a potent EGFR PROTAC degrader with DC₅₀ values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 hemihydrate also degrades HER2. SJF-1528 hemihydrate promotes ubiquitination and degradation of EGFR and can be used in breast cancer research (Pink: ligand for target protein (HY-159047); Black: linker Tos-PEG2-CH2-Boc (HY-130532); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

SJF-1528 hemihydrate 構造式

容量	価格（税別）	在庫状況	数量
1 mg	$340	在庫あり	Estimated Time of Arrival: December 31
5 mg		お問い合わせ
10 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of SJF-1528 hemihydrate:

SJF-1528 在庫あり

PROTACs アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

EGFR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

SJF-1528 (24 h) hemihydrate induces EGFR degradation in OVCAR8 cells, with a DC₅₀ of 39.2 nM, and induces degradation of the FLAG-tagged exon 20 insertion mutant EGFR in HeLa cells, with a DC₅₀ of 736.2 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1039.62

分子式

C₅₅H₅₇ClFN₇O₈S.1/2H₂O

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C([C@H]1N(C([C@@H](NC(COCCOCCOC2=CC=C(C3=CC4=C(NC5=CC=C(OCC6=CC=CC(F)=C6)C(Cl)=C5)N=CN=C4C=C3)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7.[1/2].O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 104 mg/mL (100.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9619 mL	4.8094 mL	9.6189 mL
5 mM	0.1924 mL	0.9619 mL	1.9238 mL
10 mM	0.0962 mL	0.4809 mL	0.9619 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.90%

Select Batch:

データシート (273 KB) SDS (252 KB)

COA (252 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9619 mL	4.8094 mL	9.6189 mL	24.0472 mL
	5 mM	0.1924 mL	0.9619 mL	1.9238 mL	4.8094 mL
	10 mM	0.0962 mL	0.4809 mL	0.9619 mL	2.4047 mL
	15 mM	0.0641 mL	0.3206 mL	0.6413 mL	1.6031 mL
	20 mM	0.0481 mL	0.2405 mL	0.4809 mL	1.2024 mL
	25 mM	0.0385 mL	0.1924 mL	0.3848 mL	0.9619 mL
	30 mM	0.0321 mL	0.1603 mL	0.3206 mL	0.8016 mL
	40 mM	0.0240 mL	0.1202 mL	0.2405 mL	0.6012 mL
	50 mM	0.0192 mL	0.0962 mL	0.1924 mL	0.4809 mL
	60 mM	0.0160 mL	0.0802 mL	0.1603 mL	0.4008 mL
	80 mM	0.0120 mL	0.0601 mL	0.1202 mL	0.3006 mL
	100 mM	0.0096 mL	0.0481 mL	0.0962 mL	0.2405 mL