MEGF10 Protein, Human (HEK293, Fc)

The MEGF10 protein is a membrane receptor that plays a key role in phagocytosis by macrophages and astrocytes, specifically the clearance of apoptotic cells through C1q binding to phosphatidylserine. MEGF10 cooperates with ABCA1 to contribute to the formation of large vacuoles and may facilitate amyloid-beta peptide uptake. MEGF10 Protein, Human (HEK293, Fc) is the recombinant human-derived MEGF10 protein, expressed by HEK293 , with C-hFc labeled tag.

MEGF10 Protein, a membrane receptor, plays a pivotal role in phagocytosis by macrophages and astrocytes, particularly in the clearance of apoptotic cells. As a receptor for C1q, an eat-me signal, MEGF10 binds to phosphatidylserine on the surface of apoptotic cells, facilitating their engulfment. The protein collaborates with ABCA1 during this process and contributes to the formation of large intracellular vacuoles, potentially involved in the uptake of amyloid-beta peptides. In addition to its role in apoptotic cell clearance, MEGF10 is essential for astrocyte-mediated clearance of apoptotic neurons in the developing cerebellum. Furthermore, MEGF10 influences muscle cell proliferation, adhesion, and motility, playing a crucial role in the regulation of myogenesis and the balance between skeletal muscle satellite cell proliferation and differentiation through the notch signaling pathway. Additionally, MEGF10 may contribute to the mosaic spacing of specific neuron subtypes in the retina, ensuring an even distribution across the retina for comprehensive visual field processing. The protein forms homomers and interacts with GULP1, ABCA1, AP2M1, and NOTCH1, highlighting its multifaceted roles in various cellular processes.

Human

HEK293

C-hFc

Q96KG7-1 (L26-G857)

84466  [NCBI]

Extracellular Domain

LNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQIG

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.