EGFR-IN-45
EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC50s of 0.4 µM and 1.6 µM for EGFR and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2765560-03-8
- Formula: C28H23N7O
- Molecular Weight:473.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK2 1.6 μM (IC50) |
EGFR 0.4 μM (IC50) |
EGFR-IN-45 (compound 30b) (0-10 μM; 48 hours) exhibits the high anticancer activity against Panc-1, MCF-7, HT-29 and A-549[1].
EGFR-IN-45 (20 and 100 μM; hours) can inhibit Topo I and Topo II in a dose-dependent manner[1].
EGFR-IN-45 (0-8 μM; 24 hours) has a high percentage of cell accumulation in the pre-G1 phase in MCF-7[1].
EGFR-IN-45 (0-8 μM; 24 hours) induces high amounts of apoptosis, with a necrosis percent of 2.99[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Panc-1, MCF-7, HT-29 and A-549[1]
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Concentration:0-10 μM
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Incubation Time:48 hours
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Result:Exhibited the high anticancer activity with IC50s of 0.9±0.20, 0.8±0.5, 1.3±0.3, 1.2±0.2 μM in Panc-1, MCF-7, HT-29 and A-549, respectively.
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Cell Line:MCF-7[1]
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Concentration:0, 2, 4, 6 and 8 μM
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Incubation Time:24 hours
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Result:Showed a high percentage of cell accumulation (36.02%) in the pre-G1 phase in MCF-7.
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Cell Line:MCF-7[1]
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Concentration:0, 2, 4, 6 and 8 μM
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Incubation Time:24 hours
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Result:Induced high amounts of apoptosis, with a necrosis percent of 2.99.
Chemical Information
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CAS No. 2765560-03-8
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Molecular Weight 473.53
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Formula C28H23N7O
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SMILES
NC1=NC(C2=CC=CC=C2)=NC3=C1C(NC4=CC=CC=C43)=NC5=C(C)N(C)N(C6=CC=CC=C6)C5=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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