EGFR/HER2-IN-11
EGFR/HER2-IN-11 (compound 20) is an orally active dual inhibitor for human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), with IC50s of 7.7 and 22 nM, respectively. EGFR/HER2-IN-11 exhibits antitumor efficacy and inhibits proliferation against cancer cells BT-474 with GI50 of 601 nM.
For research use only. We do not sell to patients.
- CAS No.: 1346176-20-2
- Formula: C23H21ClF3N5O2
- Molecular Weight:491.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BT-474 | GI50 |
601 nM
Compound: 20
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Growth inhibition of human BT474 cells overexpressing HER2 gene after 5 days by particle analyzer
Growth inhibition of human BT474 cells overexpressing HER2 gene after 5 days by particle analyzer
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[PMID: 22003817] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1346176-20-2
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Molecular Weight 491.89
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Formula C23H21ClF3N5O2
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SMILES
FC(F)(C1=CC(OC2=CC=C(NC3=NC=NC4=C3N(CCNCCO)C=C4)C=C2Cl)=CC=C1)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/HER2-IN-11 Related Classifications
HY-160613 Related Classifications
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