1346176-20-2
1346176-20-2
Chemical Structure
EGFR/HER2-IN-11
- CAS No.: 1346176-20-2
- Formula:C23H21ClF3N5O2
- Molecular Weight:491.89
InChIKey: ABLXXKUDDSMAHU-UHFFFAOYSA-N
SMILES: FC(F)(C1=CC(OC2=CC=C(NC3=NC=NC4=C3N(CCNCCO)C=C4)C=C2Cl)=CC=C1)F
Biological Activity: EGFR/HER2-IN-11 (compound 20) is an orally active dual inhibitor for human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), with IC50s of 7.7 and 22 nM, respectively. EGFR/HER2-IN-11 exhibits antitumor efficacy and inhibits proliferation against cancer cells BT-474 with GI50 of 601 nM[1].
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EGFR/HER2-IN-11 | EGFR/HER2-IN-11 (compound 20) is an orally active dual inhibitor for human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), with IC50s of 7.7 and 22 nM, respectively. EGFR/HER2-IN-11 exhibits antitumor efficacy and inhibits proliferation against cancer cells BT-474 with GI50 of 601 nM. | |||||||||||||||||||||
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