Tyrphostin 25
Based on 1 Customer Validation
Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.00%
- CAS 番号: 118409-58-8
- 分子式: C10H6N2O3
- 分子量:202.17
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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EGFR アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
EGFR tyrosine kinase[1]
IC50: 0.94 µM (GPR35)[2]
EC50: 5.3 µM (GPR35)[2]
体外実験
Tyrphostin 25 ((50 μM for 12-16 h) selectively prevents EGFR autophosphorylation thereby preventing the EGF-induced FG human pancreatic carcinoma cells migration response on vitronectin without affecting constitutive migration on collagen[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 118409-58-8
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性状 Solid
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分子量 202.17
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分子式 C10H6N2O3
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Color Yellow to brown
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SMILES
N#C/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1
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別名
AG82; Tyrphostin A 25; Tyrphostin AG 82; RG-50875
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 30 mg/mL (148.39 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994 Nov;127(3):859-66. [Content Brief]
[2]. Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. [Content Brief]
[3]. Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011 Jun 23;585(12):1957-62. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.9463 mL | 24.7317 mL | 49.4633 mL | 123.6583 mL |
| 5 mM | 0.9893 mL | 4.9463 mL | 9.8927 mL | 24.7317 mL | |
| 10 mM | 0.4946 mL | 2.4732 mL | 4.9463 mL | 12.3658 mL | |
| 15 mM | 0.3298 mL | 1.6488 mL | 3.2976 mL | 8.2439 mL | |
| 20 mM | 0.2473 mL | 1.2366 mL | 2.4732 mL | 6.1829 mL | |
| 25 mM | 0.1979 mL | 0.9893 mL | 1.9785 mL | 4.9463 mL | |
| 30 mM | 0.1649 mL | 0.8244 mL | 1.6488 mL | 4.1219 mL | |
| 40 mM | 0.1237 mL | 0.6183 mL | 1.2366 mL | 3.0915 mL | |
| 50 mM | 0.0989 mL | 0.4946 mL | 0.9893 mL | 2.4732 mL | |
| 60 mM | 0.0824 mL | 0.4122 mL | 0.8244 mL | 2.0610 mL | |
| 80 mM | 0.0618 mL | 0.3091 mL | 0.6183 mL | 1.5457 mL | |
| 100 mM | 0.0495 mL | 0.2473 mL | 0.4946 mL | 1.2366 mL |
Tyrphostin 25 関連分類
HY-101958 関連分類
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Keywords
- Tyrphostin 25
- 118409-58-8
- AG82
- Tyrphostin A 25
- Tyrphostin AG 82
- RG-50875
- Tyrphostin25
- Tyrphostin-25
- AG 82
- AG-82
- Tyrphostin A25
- Tyrphostin A 25
- Tyrphostin A-25
- Tyrphostin AG82
- Tyrphostin AG 82
- Tyrphostin AG-82
- RG50875
- RG 50875
- RG-50875
- EGFR
- GPR35
- G protein-coupled receptor
- epidermal growth factor receptor
- Inhibitor
- inhibitor
- inhibit