118409-58-8
118409-58-8
Chemical Structure
Tyrphostin 25
Synonym(s): AG82; Tyrphostin A 25; Tyrphostin AG 82; RG-50875
- CAS No.: 118409-58-8
- Formula:C10H6N2O3
- Molecular Weight:202.17
IUPAC Name: 2-(3,4,5-trihydroxybenzylidene)malononitrile
InChIKey: YZOFLYUAQDJWKV-UHFFFAOYSA-N
SMILES: N#C/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1
Biological Activity: Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM[1][2][3].
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Tyrphostin 25 | 99.00% | Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM. | ||||||||||||||||||||
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Tyrphostin 25 (Standard) | ≥98% | Tyrphostin 25 (Standard) (AG82 (Standard)) is the analytical standard of Tyrphostin 25 (HY-101958). This product is intended for research and analytical applications. Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM. | ||||||||||||||||||||
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References
- [1]. Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994 Nov;127(3):859-66. [Content Brief]
- [2]. Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. [Content Brief]
- [3]. Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011 Jun 23;585(12):1957-62. [Content Brief]
