1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. CNX-500

CNX-500 

Cat. No.: HY-100338 Purity: 99.19%
Handling Instructions

CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn.

For research use only. We do not sell to patients.

CNX-500 Chemical Structure

CNX-500 Chemical Structure

CAS No. : 1202758-21-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 5815 In-stock
Estimated Time of Arrival: December 31
5 mg USD 3500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 5500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn[1].

In Vitro

Used in a competition assay, CNX-500 detects free, uninhibited Btk and is excluded from interaction with Btk previously bonded by CC-292. In Ramos cells exposed to a range of CC-292 concentrations, the amount of Btk captured by the probe is compared with untreated samples and the extent of Btk bonded is demonstrated to be proportional to CC-292 drug concentration[1].

Molecular Weight

961.18

Formula

C₄₈H₆₈N₁₀O₉S

CAS No.

1202758-21-1

SMILES

O=C(NCCCOCCOCCOCCCNC(CCCC[[email protected]@H]1SC[[email protected]]([[email protected]]1([H])N2)([H])NC2=O)=O)CCCC(NCCCOC3=CC=CC(NC4=NC=C(C)C(NC5=CC=CC(NC(C=C)=O)=C5)=N4)=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

CNX-500CNX500CNX 500BtkBruton tyrosine kinaseBCRCC-292probecovalentSykLynInhibitorinhibitorinhibit

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CNX-500
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HY-100338
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