1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. CNX-500

CNX-500 

Cat. No.: HY-100338 Purity: 98.49%
Handling Instructions

CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn.

For research use only. We do not sell to patients.

CNX-500 Chemical Structure

CNX-500 Chemical Structure

CAS No. : 1202758-21-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 5815 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 5815 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 3500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 5500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn[1].

In Vitro

Used in a competition assay, CNX-500 detects free, uninhibited Btk and is excluded from interaction with Btk previously bonded by CC-292. In Ramos cells exposed to a range of CC-292 concentrations, the amount of Btk captured by the probe is compared with untreated samples and the extent of Btk bonded is demonstrated to be proportional to CC-292 drug concentration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

961.18

Formula

C₄₈H₆₈N₁₀O₉S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (52.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0404 mL 5.2019 mL 10.4039 mL
5 mM 0.2081 mL 1.0404 mL 2.0808 mL
10 mM 0.1040 mL 0.5202 mL 1.0404 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (1.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (1.30 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (1.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.19%

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Product Name:
CNX-500
Cat. No.:
HY-100338
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