2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. HIF/HIF Prolyl-Hydroxylase VEGFR
  4. 7-Hydroxyneolamellarin A

7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer.

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7-Hydroxyneolamellarin A Chemical Structure

7-Hydroxyneolamellarin A Chemical Structure

CAS No. : 959662-26-1

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7-Hydroxyneolamellarin A Related Antibodies

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Description

7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer[1].

In Vitro

7-Hydroxyneolamellarin A (0-150 μM; 12 h; Hela cells, MCF-7 cells and 4T1 cells) inhibits HIF-1 signaling pathway with low cytotoxicity[1].
7-Hydroxyneolamellarin A (0-100 μM; 12 h) reduces the mRNA levels of VEGF dose-dependently in Hela cells[1].
7-hydroxyneolamellarin A (0-50 μM; 36 h) inhibits Hela cells migration, invasion and proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7-Hydroxyneolamellarin A Related Antibodies

Western Blot Analysis[1]

Cell Line: Hela cells, MCF-7 cells and 4T1 cells
Concentration: 0, 50, 100, and 150 μM
Incubation Time: 12 hours
Result: Decreased the HIF-1α protein levels in a dose-dependent manner.
In Vivo

7-Hydroxyneolamellarin A (15 mg/kg; i.v.; BALB/c mice with 4T1 cells xenografts) inhibits tumor growth in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with 4T1 cells xenografts[1]
Dosage: 15 mg/kg
Administration: Intravenous injection; every 2 days for 16 days
Result: Inhibited tumor growth in vivo.
Molecular Weight

401.41

Formula

C24H19NO5
CAS No.
SMILES

OC1=CC=C(C(O)C(N2C=C(C3=CC=C(O)C=C3)C(C4=CC=C(O)C=C4)=C2)=O)C=C1
Structure Classification
Initial Source

Dendrilla nigra
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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7-Hydroxyneolamellarin A Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Hydroxyneolamellarin A959662-26-1HIF/HIF Prolyl-HydroxylaseVEGFRHypoxia-inducible factorsHIFsHIF-PHVascular endothelial growth factor receptorsponge Dendrilla nigranatural producttumor angiogenesisproliferationmigrationinvasion.Inhibitorinhibitorinhibit

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