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Cat. No.: HY-N10330

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7-Hydroxyneolamellarin A

7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer.

For research use only. We do not sell to patients.

CAS No.: 959662-26-1
Formula: C₂₄H₁₉NO₅
Molecular Weight:401.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

7-Hydroxyneolamellarin A Chemical Structure

CAS No.: 959662-26-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All HIF/HIF Prolyl-Hydroxylase Isoforms :

All VEGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
T47D	IC₅₀	1.9 μM Compound: 4, 7-(R/S)-Hydroxylamellarin A	Inhibition of HIF1 activation in T47D cells by reporter gene assay Inhibition of HIF1 activation in T47D cells by reporter gene assay	[PMID: 17958397]
T47D	IC₅₀	3.7 μM Compound: 4, 7-(R/S)-Hydroxylamellarin A	Inhibition of 1,10-phenanthroline-induced HIF1 activation in T47D cells by reporter gene assay Inhibition of 1,10-phenanthroline-induced HIF1 activation in T47D cells by reporter gene assay	[PMID: 17958397]

In Vitro

7-Hydroxyneolamellarin A (0-150 μM; 12 h; Hela cells, MCF-7 cells and 4T1 cells) inhibits HIF-1 signaling pathway with low cytotoxicity^[1].
7-Hydroxyneolamellarin A (0-100 μM; 12 h) reduces the mRNA levels of VEGF dose-dependently in Hela cells^[1].
7-hydroxyneolamellarin A (0-50 μM; 36 h) inhibits Hela cells migration, invasion and proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Hela cells, MCF-7 cells and 4T1 cells
Concentration:

0, 50, 100, and 150 μM
Incubation Time:

12 hours
Result:

Decreased the HIF-1α protein levels in a dose-dependent manner.

In Vivo

7-Hydroxyneolamellarin A (15 mg/kg; i.v.; BALB/c mice with 4T1 cells xenografts) inhibits tumor growth in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice with 4T1 cells xenografts^[1]
Dosage:

15 mg/kg
Administration:

Intravenous injection; every 2 days for 16 days
Result:

Inhibited tumor growth in vivo.

Chemical Information

CAS No. 959662-26-1
Molecular Weight 401.41
Formula C₂₄H₁₉NO₅
SMILES

OC1=CC=C(C(O)C(N2C=C(C3=CC=C(O)C=C3)C(C4=CC=C(O)C=C4)=C2)=O)C=C1
Structure Classification
- Phenols
Initial Source
- Animals
Dendrilla nigra
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li G, et, al. Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy. Bioorg Med Chem Lett. 2021 Oct 15;50:128338. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
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- In Vivo
Chemical Information
Purity & Documentation
References

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7-Hydroxyneolamellarin A

All HIF/HIF Prolyl-Hydroxylase Isoforms

All VEGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

7-Hydroxyneolamellarin A Related Classifications

HY-N10330 Related Classifications