1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. NRC-2694

NRC-2694 

Cat. No.: HY-19909 Purity: 99.71%
Handling Instructions

NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties.

For research use only. We do not sell to patients.

NRC-2694 Chemical Structure

NRC-2694 Chemical Structure

CAS No. : 936446-61-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 442 In-stock
Estimated Time of Arrival: December 31
1 mg USD 240 In-stock
Estimated Time of Arrival: December 31
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 816 In-stock
Estimated Time of Arrival: December 31
20 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
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Description

NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties.

IC50 & Target[1]

EGFR

 

In Vitro

NRC-2694 at 80 ng (190 nm) concentrations causes comparable inhibition of EGFR expression[1].

In Vivo

In toxicity studies, the maximum tolerated dose of NRC-2694 in male and female mice is 2000 mg/kg (po). NRC-2694 (10 mg/kg) regresses the tumor in mice[1].

Molecular Weight

418.49

Formula

C₂₄H₂₆N₄O₃

CAS No.

936446-61-6

SMILES

COC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCCN4CCOCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (597.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3895 mL 11.9477 mL 23.8954 mL
5 mM 0.4779 mL 2.3895 mL 4.7791 mL
10 mM 0.2390 mL 1.1948 mL 2.3895 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

The in vitro invasiveness of H1299 and A549 cells in the presence of various concentrations of NRC compounds (as determined by MTT assay) is assessed using a modified Boyden chamber assay. Cells are treated with these compounds for 48 hr. 1×106 cells are suspended in 600 μL of serum-free medium supplemented with 0.2% BSA and placed in the upper compartment of the transwell chambers coated with matrigel (0.7 mg/mL). The lower compartment of the chamber is filled with 200 μL of serum medium and the cells are allowed to migrate for 24 h. after incubation, the cells are fixed and stained with Hema-3 and quantified. The migrated cells are quantified as percent invasion.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Mice: Nude mice are implanted with 2×106 A549 cells in the right hind limb flank. Upon the observance of a tumour (>2 mm), mice are given oral or ip treatments of the test compounds including erlotinib HCl used as positive control. A dose of 100 mg/kg of erlotinib HCl is identified as the base line dose.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.71%

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Keywords:

NRC-2694NRC2694NRC 2694EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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Product name:
NRC-2694
Cat. No.:
HY-19909
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