Notch 1 TFA 

Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types^[1].

Notch 1 is shown to promote mouse luminal prostate cell survival and proliferation through the activation of the prosurvival NF-κB pathway^[2].
Down-regulation of Notch 1 and Jagged1 in human prostate cancer cell lines decreases in vitro invasion and cell growth^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1614.81

C₆₄H₉₈N₁₅F₃O₂₅S₃

Solid

Off-white to light yellow

NH2-CLDQIGEFQCICE-COOH

[NH2-CLDQIGEFQCICE-COOH (TFA salt)]

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. NOTCH1 notch receptor 1 [Homo sapiens (human)] Gene ID: 4851, updated on 28-Oct-2019.

  [2]. Stoyanova T, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6457-E6466.  [Content Brief]