1. Neuronal Signaling
    Stem Cell/Wnt
  2. Notch
  3. Notch 1 TFA

Notch 1 TFA 

Cat. No.: HY-P1985A
Handling Instructions

Notch 1 TFA (Notch homolog 1, translocation-associated) is a human gene. This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types.

For research use only. We do not sell to patients.

Notch 1 TFA Chemical Structure

Notch 1 TFA Chemical Structure

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Description

Notch 1 TFA (Notch homolog 1, translocation-associated) is a human gene. This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types[1].

In Vitro

Notch 1 is shown to promote mouse luminal prostate cell survival and proliferation through the activation of the prosurvival NF-κB pathway[2].
Down-regulation of Notch 1 and Jagged1 in human prostate cancer cell lines decreases in vitro invasion and cell growth[2].

Molecular Weight

1614.81

Formula

C₆₄H₉₈N₁₅F₃O₂₅S₃

Sequence

NH2-Cys-Leu-Asp-Gln-Ile-Gly-Glu-Phe-Gln-Cys-Ile-Cys-Glu-COOH

Sequence Shortening

NH2-CLDQIGEFQCICE-COOH

SMILES

O=C(O)C(F)(F)F.[NH2-CLDQIGEFQCICE-COOH]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Notch 1Notch1Notch-1NotchInhibitorinhibitorinhibit

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Notch 1 TFA
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HY-P1985A
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