AZ12253801
AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ∼10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR)–driven proliferation is 440 nmol/L. Anti-tumor activity.
For research use only. We do not sell to patients.
- CAS No.: 851432-37-6
- Formula: C21H22N8O
- Molecular Weight:402.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 851432-37-6
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Molecular Weight 402.45
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Formula C21H22N8O
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SMILES
[H][C@](CCC1)(C2=CC(C3=CC=CC=N3)=NO2)N1C4=NC(C)=CC(NC5=NNC(C)=C5)=N4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZ12253801 Related Classifications
HY-125102 Related Classifications
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