851432-37-6
Chemical Structure
AZ12253801
- CAS No.: 851432-37-6
- Formula:C21H22N8O
- Molecular Weight:402.45
IUPAC Name: (S)-6-methyl-N-(5-methyl-1H-pyrazol-3-yl)-2-(2-(3-(pyridin-2-yl)isoxazol-5-yl)pyrrolidin-1-yl)pyrimidin-4-amine
InChIKey: KHGNDLZELXNRQC-KRWDZBQOSA-N
SMILES: [H][C@](CCC1)(C2=CC(C3=CC=CC=N3)=NO2)N1C4=NC(C)=CC(NC5=NNC(C)=C5)=N4
Biological Activity: AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ∼10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR)–driven proliferation is 440 nmol/L. Anti-tumor activity.
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AZ12253801 | AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ∼10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR)–driven proliferation is 440 nmol/L. Anti-tumor activity. | |||||||||||||||||||||
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