2. MAPK/ERK Pathway Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Neuronal Signaling Membrane Transporter/Ion Channel
  3. ERK EGFR Reactive Oxygen Species Calcium Channel
  4. PACAP-38 (31-38), human, mouse, rat

PACAP-38 (31-38), human, mouse, rat 

Cat. No.: HY-P1845 Purity: 99.25%
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PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research.

For research use only. We do not sell to patients.

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PACAP-38 (31-38), human, mouse, rat Chemical Structure

PACAP-38 (31-38), human, mouse, rat Chemical Structure

CAS No. : 138764-85-9

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500 μg USD 100 In-stock
1 mg USD 150 In-stock
5 mg USD 450 In-stock
10 mg USD 670 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of PACAP-38 (31-38), human, mouse, rat:

PACAP-38 (31-38), human, mouse, rat Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research[1][2][3].

In Vitro

PACAP-38 (31-38), human, mouse, rat (100 nM; 2 min; NCI-H838 cells) induces EGFR, HER2 and ERK tyrosine phosphorylation[1].
PACAP-38 (31-38), human, mouse, rat (100 nM; 30 min; NCI-H838 cells) induces EGFR tyrosine phosphorylation with generates ROS and increases ROS levels by 51%[1].
PACAP-38 (31-38), human, mouse, rat (10 nM; 48 h) stimulates the growth of NCI-H838 cells[1].
PACAP-38 (31-38), human, mouse, rat (300 nM; 4 h) stimulates generation of APPsα in neural cells[2].
PACAP-38 (31-38), human, mouse, rat (0.01-10 nM; HEK 293 cells) stimulates neural cells express endogenous PAC1 receptors by cAMP accumulation and by an increase in cytosolic free calcium and induces elevation of the intracellular Ca2+ concentration in a dose-dependent manner with an EC50 value of 0.81 nM[2].
PACAP-38 (31-38), human, mouse, rat (0.01 nM; 48 h) elicits potent and efficacious stimulation of NPY secretion from SCG neuronal cultures[3].
PACAP-38 (31-38), human, mouse, rat (100 nM; 14 d) produces sustained stimulated NPY and catecholamine secretionmpathetic neurons[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PACAP-38 (31-38), human, mouse, rat Related Antibodies

Cell Viability Assay[1]

Cell Line: NCI-H838 cells
Concentration: 10 nM
Incubation Time: 48 hours
Result: Increased the number of NCI-H838 cells by 72%.

Western Blot Analysis[1]

Cell Line: 100 nM
Concentration: 100 nM
Incubation Time: 2 minutes
Result: Increased tyrosine phosphorylation of the EGFR, HER2, and ERK by 377, 299 and 216%, respectively.
Molecular Weight

1062.27

Formula

C47H83N17O11
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
Sequence Shortening

YKQRVKNK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (94.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9414 mL 4.7069 mL 9.4138 mL
5 mM 0.1883 mL 0.9414 mL 1.8828 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9414 mL 4.7069 mL 9.4138 mL 23.5345 mL
5 mM 0.1883 mL 0.9414 mL 1.8828 mL 4.7069 mL
10 mM 0.0941 mL 0.4707 mL 0.9414 mL 2.3535 mL
15 mM 0.0628 mL 0.3138 mL 0.6276 mL 1.5690 mL
20 mM 0.0471 mL 0.2353 mL 0.4707 mL 1.1767 mL
25 mM 0.0377 mL 0.1883 mL 0.3766 mL 0.9414 mL
30 mM 0.0314 mL 0.1569 mL 0.3138 mL 0.7845 mL
40 mM 0.0235 mL 0.1177 mL 0.2353 mL 0.5884 mL
50 mM 0.0188 mL 0.0941 mL 0.1883 mL 0.4707 mL
60 mM 0.0157 mL 0.0784 mL 0.1569 mL 0.3922 mL
80 mM 0.0118 mL 0.0588 mL 0.1177 mL 0.2942 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PACAP-38 (31-38), human, mouse, rat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PACAP-38 (31-38), human, mouse, rat138764-85-9ERKEGFRReactive Oxygen SpeciesCalcium ChannelExtracellular signal regulated kinasesEpidermal growth factor receptorErbB-1HER1Ca2+ channelsCa channelsPAC1cAMPCa2+HER2 ERKROS NPYcatecholamineInhibitorinhibitorinhibit

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