α-CGRP (mouse, rat)
Based on 9 publication(s) in Google Scholar
α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.80%
- CAS 番号: 83651-90-5
- 分子式: C162H262N50O52S2
- 分子量:3806.25
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 α-CGRP (mouse, rat)
More- Nat Commun. 2026 Mar 19. [Abstract]
- Adv Sci (Weinh). 2025 Apr;12(14):e2409251. [Abstract]
- Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]
- Mater Today Bio. 2025 Aug 14:34:102181. [Abstract]
- Mater Today Bio. 2025 Apr 17:32:101750. [Abstract]
- Br J Pharmacol. 2024 Sep;181(17):3136-3159. [Abstract]
- Cell Mol Life Sci. 2024 Aug 28;81(1):373. [Abstract]
- Int Immunopharmacol. 2026 Feb 1:170:116080. [Abstract]
- Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):60. [Abstract]
Customer Validation & Images
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In Vivo Efficacy Study
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ELISA
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Histological Imaging/Staining
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IF
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RT-PCR
生物活性
α-CGRP (mouse, rat) plays an important role in the regulation of Kainic acid (KA) induced pyramid-cell death in hippocampal CA3 region[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 83651-90-5
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性状 Solid
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分子量 3806.25
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分子式 C162H262N50O52S2
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Color White to off-white
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別名
CGRP (83-119), mouse, rat
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配列
Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
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シーケンスの短縮
SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (Disulfide bridge:Cys2-Cys7)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (9)
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Journal Impact Factor
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Most Recent
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Nat Commun
Low-intensity focused ultrasound-activated piezoelectric gel bandage for diabetic wound repair and neuropathic pain relief. [Abstract]2026 Mar 19. PMID: 41857055 -
Adv Sci (Weinh)
Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis. [Abstract]2025 Apr;12(14):e2409251. PMID: 39960341 -
Sci Adv
Prdm12 governs an epigenetic checkpoint linking neuroimmune cross-talk to CD8+ T cell exhaustion-suppressed antitumor immunity. [Abstract]2025 Aug 15;11(33):eadx9221. PMID: 40815657
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]
CGRP stimulation (100 nM, 96 hours) up-regulated the expression of Prdm12 and Ramp1.
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]
Wild-type CD8+ T cells treated with CGRP (100 nM, 96 hours) exhibited an elevated frequency of PD-1+TIM-3+ cells, whereas this effect was reversed by Prdm12 knockout (KO).
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]
Wild-type CD8+ T cells treated with CGRP (100 nM, 96 hours) exhibited a reduced frequency of CD107a+ cells, and Prdm12 KO abrogated this reduction.
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Mater Today Bio
CGRP-releasing PLGA/nHA/GO composite microspheres enhance distraction osteogenesis via activation of the cAMP/PKA/CREB pathway. [Abstract]2025 Aug 14:34:102181. PMID: 40893374 -
Mater Today Bio
Sequential SDF-1/CGRP-releasing smart composite hydrogel promotes osteoporotic fracture healing by targeting sensory nerve-regulated bone remodeling. [Abstract]2025 Apr 17:32:101750. PMID: 40331153 -
Br J Pharmacol
Naringenin relieves paclitaxel-induced pain by suppressing calcitonin gene-related peptide signalling and enhances the anti-tumour action of paclitaxel. [Abstract]2024 Sep;181(17):3136-3159. PMID: 38715438 -
Cell Mol Life Sci
Sensory nerves drive migration of dental pulp stem cells via the CGRP-Ramp1 axis in pulp repair. [Abstract]2024 Aug 28;81(1):373. PMID: 39196292 -
Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2026 Feb 1:170:116080. PMID: 41429063
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Feb 1:170:116080. [Abstract]
CGRP (50 μg/kg, intraperitoneal injection,on days 1, 2, and 3) reduced the frequency and severity of epileptic seizures mice induced by Kainic acid(1 μL, 250 ng/μL,single ).
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Feb 1:170:116080. [Abstract]
CGRP (50 μg/kg, intraperitoneal injection, on days 1, 2, and 3) reduced the expression of pro-inflammatory cytokines (including IL-1β, IL-6, and TNF-α) in the brain tissues of epileptic mice induced by kainic acid.
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Feb 1:170:116080. [Abstract]
CGRP (50 μg/kg, intraperitoneal injection, on days 1, 2, and 3) mitigated pathological damage in the CA1 and CA3 regions of the hippocampus in epileptic mice induced by kainic acid, as revealed by hematoxylin and eosin staining (left) and Nissl staining (right).
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Feb 1:170:116080. [Abstract]
CGRP (50 μg/kg, intraperitoneal injection,on days 1, 2, and 3) reduced epilepsy-induced hippocampal apoptosis and neuronal loss in epilepsy mice induced by Kainic acid .
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Invest Ophthalmol Vis Sci
Corneal Nerves Promote Alkali Burn Repair by Modulating Macrophages and Neutrophils via Calcitonin Gene-Related Peptide. [Abstract]2026 Apr 1;67(4):60. PMID: 42041175
溶剤 & 溶解度
H2O : ≥ 100 mg/mL (26.27 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (290 KB)
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SDS (254 KB)
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- Deutsch - DE (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Whitby K, et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol. 2005 Jul;79(14):8698-706. [Content Brief]
[2]. Xu H, et al. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):696-708.e9. [Content Brief]
[3]. Arulmani U, et al. Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats. Basic Clin Pharmacol Toxicol. 2004 Jun;94(6):291-7. [Content Brief]
[4]. Park SH, et al. Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice. Peptides. 2013 Jun;44:158-62. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.2627 mL | 1.3136 mL | 2.6273 mL | 6.5681 mL |
| 5 mM | 0.0525 mL | 0.2627 mL | 0.5255 mL | 1.3136 mL | |
| 10 mM | 0.0263 mL | 0.1314 mL | 0.2627 mL | 0.6568 mL | |
| 15 mM | 0.0175 mL | 0.0876 mL | 0.1752 mL | 0.4379 mL | |
| 20 mM | 0.0131 mL | 0.0657 mL | 0.1314 mL | 0.3284 mL | |
| 25 mM | 0.0105 mL | 0.0525 mL | 0.1051 mL | 0.2627 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
α-CGRP (mouse, rat) 関連分類
HY-P0203 関連分類
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