α-CGRP (mouse, rat)
Based on 8 publication(s) in Google Scholar
α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 83651-90-5
- Formula: C162H262N50O52S2
- Molecular Weight:3806.25
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) α-CGRP (mouse, rat)
More- Nat Commun. 2026 Mar 19. [Abstract]
- Adv Sci (Weinh). 2025 Apr;12(14):e2409251. [Abstract]
- Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]
- Mater Today Bio. 2025 Aug 14:34:102181. [Abstract]
- Mater Today Bio. 2025 Apr 17:32:101750. [Abstract]
- Br J Pharmacol. 2024 May 7. [Abstract]
- Cell Mol Life Sci. 2024 Aug 28;81(1):373. [Abstract]
- Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]
Customer Validation & Images
-
RT-PCR
-
Flow Cytometry
-
Flow Cytometry
-
In Vivo Efficacy Study
-
ELISA
Biological Activity
α-CGRP (mouse, rat) plays an important role in the regulation of Kainic acid (KA) induced pyramid-cell death in hippocampal CA3 region[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 83651-90-5
-
Appearance Solid
-
Molecular Weight 3806.25
-
Formula C162H262N50O52S2
-
Color White to off-white
-
Synonyms
CGRP (83-119), mouse, rat
-
Sequence
Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
-
Sequence Shortening
SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (Disulfide bridge:Cys2-Cys7)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (8)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
Low-intensity focused ultrasound-activated piezoelectric gel bandage for diabetic wound repair and neuropathic pain relief. [Abstract]2026 Mar 19. PMID: 41857055 -
Adv Sci (Weinh)
Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis. [Abstract]2025 Apr;12(14):e2409251. PMID: 39960341 -
Sci Adv
Prdm12 governs an epigenetic checkpoint linking neuroimmune cross-talk to CD8+ T cell exhaustion-suppressed antitumor immunity. [Abstract]2025 Aug 15;11(33):eadx9221. PMID: 40815657
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]
CGRP stimulation (100 nM, 96 hours) up-regulated the expression of Prdm12 and Ramp1.
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]
Wild-type CD8+ T cells treated with CGRP (100 nM, 96 hours) exhibited an elevated frequency of PD-1+TIM-3+ cells, whereas this effect was reversed by Prdm12 knockout (KO).
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]
Wild-type CD8+ T cells treated with CGRP (100 nM, 96 hours) exhibited a reduced frequency of CD107a+ cells, and Prdm12 KO abrogated this reduction.
-
Mater Today Bio
CGRP-releasing PLGA/nHA/GO composite microspheres enhance distraction osteogenesis via activation of the cAMP/PKA/CREB pathway. [Abstract]2025 Aug 14:34:102181. PMID: 40893374 -
Mater Today Bio
Sequential SDF-1/CGRP-releasing smart composite hydrogel promotes osteoporotic fracture healing by targeting sensory nerve-regulated bone remodeling. [Abstract]2025 Apr 17:32:101750. PMID: 40331153 -
Br J Pharmacol
Naringenin relieves paclitaxel-induced pain by suppressing calcitonin gene-related peptide signalling and enhances the anti-tumour action of paclitaxel. [Abstract]2024 May 7. PMID: 38715438 -
Cell Mol Life Sci
Sensory nerves drive migration of dental pulp stem cells via the CGRP-Ramp1 axis in pulp repair. [Abstract]2024 Aug 28;81(1):373. PMID: 39196292 -
Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2025 Dec 21:170:116080. PMID: 41429063
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]
CGRP (50 μg/kg, intraperitoneal injection,on days 1, 2, and 3) reduced the frequency and severity of epileptic seizures mice induced by Kainic acid(1 μL, 250 ng/μL,single ).
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]
CGRP (50 μg/kg, intraperitoneal injection, on days 1, 2, and 3) reduced the expression of pro-inflammatory cytokines (including IL-1β, IL-6, and TNF-α) in the brain tissues of epileptic mice induced by kainic acid.
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]
CGRP (50 μg/kg, intraperitoneal injection, on days 1, 2, and 3) mitigated pathological damage in the CA1 and CA3 regions of the hippocampus in epileptic mice induced by kainic acid, as revealed by hematoxylin and eosin staining (left) and Nissl staining (right).
α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]
CGRP (50 μg/kg, intraperitoneal injection,on days 1, 2, and 3) reduced epilepsy-induced hippocampal apoptosis and neuronal loss in epilepsy mice induced by Kainic acid .
Solvent & Solubility
H2O : ≥ 100 mg/mL (26.27 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (290 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
-
Handling Instructions (2659 KB)
References
[1]. Whitby K, et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol. 2005 Jul;79(14):8698-706. [Content Brief]
[2]. Xu H, et al. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):696-708.e9. [Content Brief]
[3]. Arulmani U, et al. Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats. Basic Clin Pharmacol Toxicol. 2004 Jun;94(6):291-7. [Content Brief]
[4]. Park SH, et al. Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice. Peptides. 2013 Jun;44:158-62. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.2627 mL | 1.3136 mL | 2.6273 mL | 6.5681 mL |
| 5 mM | 0.0525 mL | 0.2627 mL | 0.5255 mL | 1.3136 mL | |
| 10 mM | 0.0263 mL | 0.1314 mL | 0.2627 mL | 0.6568 mL | |
| 15 mM | 0.0175 mL | 0.0876 mL | 0.1752 mL | 0.4379 mL | |
| 20 mM | 0.0131 mL | 0.0657 mL | 0.1314 mL | 0.3284 mL | |
| 25 mM | 0.0105 mL | 0.0525 mL | 0.1051 mL | 0.2627 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Powered by Bioz