EGFR-IN-69
Based on 1 Customer Validation
EGFR-IN-69 (compound 17g) is a potent EGFR inhibitor, with IC50 values of 4.3, 6.6 and 25.6 nM against EGFRL858R/T790M/C797S, EGFRL858R/T790M, and EGFR19del/T790M/C797S, respectively. EGFR-IN-69 can be used for non-small-cell-lung-cancer (NSCLC) research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.58%
- No. CAS: 2433837-65-9
- Fòrmula: C31H37Cl2N7O3S
- Peso molecular:658.64
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
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EGFR L858R/T790M/C797S 4.3 ± 0.9 nM (IC50) |
EGFRL858R/T790M 6.6 ± 0.8 nM (IC50) |
EGFRdel19 T790M C797S 25.6 ± 7.5 nM (IC50) |
EGFRWT 816.0 ± 82 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| BaF3 | IC50 |
2.61 μM
Compound: 17g
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Antiproliferative activity against mouse BaF3 cells stably expressing EGFR L858R/T790M/C797S mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells stably expressing EGFR L858R/T790M/C797S mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 35446588] |
| BaF3 | IC50 |
4.92 μM
Compound: 17g
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Cytotoxicity against mouse IL-3 dependent BaF3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Cytotoxicity against mouse IL-3 dependent BaF3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 35446588] |
Chemical Information
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No. CAS 2433837-65-9
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Appearance Solid
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Peso molecular 658.64
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Fòrmula C31H37Cl2N7O3S
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Color Light yellow to yellow
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SMILES
O=S(N1C=C(C2=NC(NC3=CC(Cl)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3OC)=NC=C2Cl)C6=C1C=CC=C6)(CC)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 12.5 mg/mL (18.98 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5183 mL | 7.5914 mL | 15.1828 mL | 37.9570 mL |
| 5 mM | 0.3037 mL | 1.5183 mL | 3.0366 mL | 7.5914 mL | |
| 10 mM | 0.1518 mL | 0.7591 mL | 1.5183 mL | 3.7957 mL | |
| 15 mM | 0.1012 mL | 0.5061 mL | 1.0122 mL | 2.5305 mL |
EGFR-IN-69 Related Classifications
HY-150610 Related Classifications
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