1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. Lavendustin A

Lavendustin A (Synonyms: RG-14355)

Cat. No.: HY-18963
Handling Instructions

Lavendustin A (RG-14355), isolated from Streptomyces Griseolavendus, is a potent, specific and ATP-competitive inhibitor of tyrosine kinase, with an IC50 of 11 ng/mL for EGFR-associated tyrosine kinase. It suppresses VEGF-induced angiogenesis and blocks the induction of LTPGABA-A.

For research use only. We do not sell to patients.

Lavendustin A Chemical Structure

Lavendustin A Chemical Structure

CAS No. : 125697-92-9

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1 mg USD 90 Get quote
5 mg USD 180 Get quote
10 mg USD 280 Get quote
25 mg USD 590 Get quote

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Description

Lavendustin A (RG-14355), isolated from Streptomyces Griseolavendus, is a potent, specific and ATP-competitive inhibitor of tyrosine kinase, with an IC50 of 11 ng/mL for EGFR-associated tyrosine kinase[1]. It suppresses VEGF-induced angiogenesis and blocks the induction of LTPGABA-A[2][3].

IC50 & Target

IC50: 11 ng/mL (EGFR-associated tyrosine kinase)[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (655.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6221 mL 13.1103 mL 26.2206 mL
5 mM 0.5244 mL 2.6221 mL 5.2441 mL
10 mM 0.2622 mL 1.3110 mL 2.6221 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.45 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

381.38

Formula

C₂₁H₁₉NO₆

CAS No.

125697-92-9

SMILES

O=C(O)C1=CC(N(CC2=CC(O)=CC=C2O)CC3=CC=CC=C3O)=CC=C1O

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Lavendustin A
Cat. No.:
HY-18963
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Lavendustin A

Cat. No.: HY-18963