125697-92-9
125697-92-9
Chemical Structure
Lavendustin A
Synonym(s): RG-14355
- CAS. Nr.: 125697-92-9
- Formula:C21H19NO6
- Molecular Weight:381.38
IUPAC Name: 5-((2,5-dihydroxybenzyl)(2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
InChIKey: ULTTYPMRMMDONC-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(N(CC2=CC(O)=CC=C2O)CC3=CC=CC=C3O)=CC=C1O
Biological Activity: Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis[1][2].
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Lavendustin A | 99.09% | Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis. | ||||||||||||||||||||
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Lavendustin A (Standard) | ≥98% | Lavendustin A (Standard) is the analytical standard of Lavendustin A. This product is intended for research and analytical applications. Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.86
HY-108935Lavendustin B -
Similarity Score 0.69
HY-114667Lavendustin C6 -
Similarity Score 0.65
HY-W013857Lavendustin C -
Similarity Score 0.55
![4,4''-Dihydroxy-[1,1':4',1''-terphenyl]-3,3''-dicarboxylicacid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w113018.gif)
HY-W1130184,4''-Dihydroxy-[1,1':4',1''-terphenyl]-3,3''-dicarboxylicacid -
Similarity Score 0.54
HY-120145MST-312 -
Similarity Score 0.54
HY-W1122975-(Bis(4-carboxybenzyl)amino)-isophthalic acid -
Similarity Score 0.54
![Bis-5-[[(3-carboxyphenyl)methyl]amino]-1,3-benzenedicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w586896.gif)
HY-W586896Bis-5-[[(3-carboxyphenyl)methyl]amino]-1,3-benzenedicarboxylic acid -
Similarity Score 0.53
![4,4′-[[(4-Carboxyphenyl)imino]bis(methylene)]bis[benzoic acid] Chemical Structure](//file.medchemexpress.com/product_pic/hy-w586874.gif)
HY-W5868744,4′-[[(4-Carboxyphenyl)imino]bis(methylene)]bis[benzoic acid] -
Similarity Score 0.53
HY-147666α-Synuclein inhibitor 4 -
Explore the MedChemAI to find more analogs
![4,4''-Dihydroxy-[1,1':4',1''-terphenyl]-3,3''-dicarboxylicacid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w113018.gif)
![Bis-5-[[(3-carboxyphenyl)methyl]amino]-1,3-benzenedicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w586896.gif)
![4,4′-[[(4-Carboxyphenyl)imino]bis(methylene)]bis[benzoic acid] Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w586874.gif)
References
- [1]. Onoda T, et, al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989 Nov-Dec;52(6):1252-7. [Content Brief]
- [2]. Hu DE, et, al. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114(2):262-8. [Content Brief]
