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Cat. No.: HY-149517

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EGFR/BRAFV600E-IN-2

EGFR/BRAFV600E-IN-2 (compound 3g) is a potential multi-target inhibitor of EGFR, BRAF^V600E, and EGFR^T790M, and an inducer of apoptosis. EGFR/BRAFV600E-IN-2 can activate caspase-3, 8, and Bax, and downregulate the anti-apoptotic protein Bcl2, inducing apoptosis. EGFR/BRAF V600E-IN-2 also has antioxidant activity and DPPH free radical scavenging potency.

For research use only. We do not sell to patients.

Formula: C₂₅H₁₈N₄O₂
Molecular Weight:406.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

EGFR/BRAFV600E-IN-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

BRaf^V600E

EGFR^T790M

Caspase-8

Caspase-3

Bcl-2

Bax

All EGFR Isoforms :

All Raf Isoforms :

All Caspase Isoforms :

All Bcl-2 Family Isoforms :

In Vitro

EGFR/BRAFV600E-IN-2 (comound 3g) effectively inhibits four human cancer cell lines: Panc-1 (pancreatic cancer cell line), MCF-7 (breast cancer cell line), HT-29 (colon cancer cell line), and A-549 (human epithelial cancer cell line), with better effective activity than Erlotinib (HY-50896)^[1].
EGFR/BRAFV600E-IN-2 displays promising antioxidant activity at 10 µM, with DPPH radical scavenging of 70.6%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

A-549, MCF-7, Panc-1, HT-29 cells
Concentration:
Incubation Time:
Result:

Inhibited cell viability among above cancer cells, with IC₅₀ of 24 nM (A-549), 28 nM (MCF-7), 26 nM (Panc-1), 26 nM (HT-29), respectively.

Chemical Information

Molecular Weight 406.44
Formula C₂₅H₁₈N₄O₂
SMILES

O=C1NC2=C(C=C(C)C=C2)C(N3N=NC(C(C4=CC=CC=C4)=O)=C3C5=CC=CC=C5)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. El-Sheref EM, et al. Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors. Int J Mol Sci. 2023 Aug 27;24(17):13300. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
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Quantity:

EGFR/BRAFV600E-IN-2

All EGFR Isoforms

All Raf Isoforms

All Caspase Isoforms

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EGFR/BRAFV600E-IN-2 Related Classifications

HY-149517 Related Classifications